Gooch and Housego Plc

Spectral Molecular Imaging Inc.

Chromodynamics, Inc.

Elliot S Wachman

Jill Wachman

Daniel L Farkas

Stanley J Geyer

Miriam Farkas

Joel M Recht

Christopher N Pannell

Erik H Lindsley

A method of removing a potential false positive result in a stained sample. The method includes the steps of: acquiring a spectral image set of a stained sample; performing linear spectral unmixing of the spectral image set to obtain a plurality of rule images; calculating an error image for the stained sample; thresholding at least one of the plurality of rule images, wherein thresholding is based on the error image; and removing a potential false positive result from the at least one of the plurality of rule images based on thresholding.

Use of error image for unmixing artifact removal in linear spectral unmixing

An imaging system includes a platform for placement of a sample or an animal to be imaged, and at least one excitation light source for irradiating the sample or animal to stimulate an emission at a plurality of different center wavelengths. An acousto-optic tunable filter (AOTF) is provided that includes a piezoelectric transducer crystal for emitting an acoustic wave having a ground electrode disposed on one side of the piezoelectric crystal. A patterned electrode layer is disposed on a side of the piezoelectric crystal opposite the ground electrode. The patterned electrode layer includes a continuous region proximate to its center and a discontinuous region, a pattern in the discontinuous region comprising a plurality of spaced apart features electrically connected to the continuous region, and an AO interaction crystal receiving the acoustic wave attached to the ground electrode or the patterned electrode layer.

AOTF-based imaging system and method for hyperspectral and multispectral imaging of specimens including medical tissue

An apparatus for image elastic scattering spectroscopy is disclosed that is comprised of a light source for generating polarized light. Means are provided to convey the polarized light to a target. A collector receives light reflected from the target. A detector is responsive to the collector for generating images at both parallel and perpendicular polarizations for each of a plurality of wavelengths. A range finder detects a distance to the target. Control electronics control the image generation and the range finder. The apparatus may be configured to image areas on the surface of the body or configured so as to be inserted into various body cavities. Typically, the apparatus will be used in conjunction with an analyzer for analyzing the images for evidence of abnormal cells. Methods of gathering data and of screening for abnormal cells are also disclosed.

Imaging elastic scattering spectroscopy

The present disclosure involves a method of preparing a cervical sample for medical examination in which a papanicolaou stained sample is additionally stained with a label targeted to one or more high risk cancer markers to allow for optical detection of the human papilloma virus. That optical detection can be combined with morphometric detection of abnormal cells, which may be improved by multispectral imaging using an acousto-optic tunable filter. Several variations of screening methods and an apparatus for performing the methods are disclosed.

Automated pap screening using optical detection of HPV with or without multispectral imaging

An acousto-optic (AO) device for generating a highly apodized acoustic wave field includes a piezoelectric transducer crystal for emitting an acoustic wave having a ground electrode disposed on one side of the piezoelectric crystal, and a patterned electrode layer disposed on a side of the piezoelectric crystal opposite the ground electrode. The patterned electrode layer includes a continuous region proximate to its center and a discontinuous region, a pattern in the discontinuous region including a plurality of spaced apart features electrically connected to the continuous region. An AO interaction crystal which receives the acoustic wave is attached to the ground electrode or the patterned electrode layer. A feature size of the features in the pattern are sufficiently small to provide a fine structure far field condition for the acoustic wave in the AO interaction crystal underlying the discontinuous region beginning &#x3c;5 mm measured from an interface between the piezoelectric crystal and the AO interaction crystal.

Growing community of inventors

Lakewood, NJ, United States of America

Elliot S Wachman