University of California

Metronom Health, Inc.

Other

University of Massachusetts

Elliot Botvinick

Troy M Bremer

Michael W Berns

John Weidling

Samir Shreim

Sean Michael White

Thoru Pederson

Vasan Venugopalan

Jonathan Compton

Amy Hellman

Linda Zhixia Shi

Maxwell Kotlarchyk

Craig Rappaport

Provided herein is a stabilized oxygen transport matrix that includes a reversible oxygen binding protein, such as hemoglobin, immobilized throughout the stabilized oxygen transport matrix. The stabilized oxygen transport matrix is used to transport oxygen and can be used as an oxygen transport region and a reaction region of an analyte sensor, such as an implantable glucose sensor. The reversible binding protein can also function as an oxygen probe within the analyte sensor.

Implantable biosensor and methods of use thereof

Disclosed herein are embodiments of a continuous analyte sensor that can be used to measure glucose or lactate levels in a patient, along with other analytes. In some embodiments, the sensor can be located in the tissue or a blood vessel of a patient, and a probe can be located on the skin of the patient generally adjacent to the sensor. The probe can detect luminescent signals that originate from the sensor and that are dependent on analyte levels.

Continuous analyte sensor

A method and device are disclosed for inducing mechanical stress in a cellular sample to evaluate mechanotransduction in the cellular sample. In one embodiment, the mechanical stress is induced by generating a microcavitation bubble in the cellular sample using a pulsed energy. The microcavitation bubble creates a microtsunami, which provides a transient, impulsive mechanical stress on the cellular sample, forming a gradient of effects at distances away from the microcavitation bubble.

Mechanical stress response analysis of cells and tissues

Disclosed herein are embodiments of methods and techniques for measuring oxygen levels of an implant. The implant can have a plurality of oxygen-sensitive microparticles incorporated throughout. The oxygen-sensitive microparticles can receive light and emit excitation light in response. The levels of excitation light emitted can be directly related to oxygen concentration in the implant.

Measuring oxygen levels in an implant, and implants having incorporated oxygen sensing

This invention relates to optomechanical systems and methods for altering, modifying or disrupting a target object. Such systems and methods are used for, for example, ablating the endogenous nucleus in a cell.

Systems and methods for identifying and disrupting cellular organelles

An apparatus and method for providing a gradient strain to an extracellular matrix to induce mechanotransduction. The gradient strain can be produced by adhering the extracellular matrix to a post and the walls of a sample holder, and then rotating the post and the sample holder. This strain can result in increased stiffness of the extracellular matrix with very little loss of pore size.

Concentration independent modulation of local micromechanics in a fibrin gel

A microscope fluid applicator includes an immersion fluid reservoir for storing immersion fluid and an applicator tip coupled to the immersion fluid reservoir. The microscope fluid applicator is releasably engaged to a moveable turret on a microscope. The microscope fluid applicator may be secured to an objective lens port on a turret of a microscope via threads. Immersion fluid is ejected from the applicator tip onto a sample holder. The turret may be rotated to place an immersion fluid objective into the immersion fluid. The sample may then be viewed through the immersion fluid. Any excess immersion fluid that is dispensed from the applicator tip may be collected in a fluid collector to prevent contamination of the microscope optics and other components.

Growing community of inventors

Irvine, CA, United States of America

Elliot Botvinick