University of Georgia Research Foundation, Inc.

Trinity Therapeutics, Inc.

Middle Tennessee State University

Peptide Biosciences, Inc.

Zolaris Biosciences, LLC

Elliot Altman

Neil M Bodie

Mark Andrew Eiteman

Ying Gao

Ravi R Gokarn

Hyo Park

Anthony Farone

Shannon Smith

Stephen Wright

Jennifer R Walker

Karen Maynard

Renee Bodie

This disclosure describes a composition including the ginsenoside 20(S)-Rg3 (also referred to herein as Rg3) and methods of using such a composition. In some embodiments, the composition may be used to treat or prevent an alpha herpesvirus including, for example, herpes simplex virus (HSV)-1 and HSV-2. In some embodiments, the composition is substantially free of other ginsenosides.

Compositions including ginsenoside 20(S)-Rg3 and methods of using ginsenoside 20(S)-Rg3 to inhibit alpha herpesvirus

The cis-isomer and trans-isomers of the plant-derived compound gnetin H are shown have anticancer properties, anti-inflammatory properties, and low toxicity. Therapeutic and prophylactic compositions that contain cis-gnetin H, trans-gnetin H, and derivatives thereof, as well as methods of making and using said compositions, are provided. cis-gnetin H and/or trans-gnetin H can be used in purified form or as a plant extract.

Cis-gnetin H and trans-gnetin H as therapeutic agents

2-Dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione (DMDD), as well as variants, derivatives, analogs, modifications, and conjugates thereof, are identified as therapeutic agents for treating or preventing human cancers and precancerous conditions. DMDD can be isolated from the root of, commonly known as starfruit. Pharmaceutical and nutraceutical compositions, as well as dietary supplements, are provided, as are methods of administration and treatment.

2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione as a cancer therapeutic

Polypeptides and other compounds that can bind specifically to the C2-C3 cleft of an immunoglobulin molecule, and methods for using such polypeptides and compounds to inhibit Fc-mediated immune complex formation, are described.

Methods for inhibiting immune complex formation in a subject

An intracellular selection system allows screening for peptide bioactivity and stability. Randomized recombinant peptides are screened for bioactivity in a tightly regulated expression system, preferably derived from the wild-type lac operon. Bioactive peptides thus identified are inherently protease- and peptidase-resistant. Also provided are bioactive peptides stabilized by a stabilizing group at the N-terminus, the C-terminus, or both. The stabilizing group can be a small stable protein, such as the Rop protein, glutathione sulfotransferase, thioredoxin, maltose binding protein, or glutathione reductase, an &#x3b1;-helical moiety, or one or more proline residues.

Stabilizied bioactive peptides and methods of identification, synthesis and use

Compositions for inhibiting immune complex formation in a subject

Stabilized bioactive peptides and methods of identification, synthesis, and use

Biological method for conversion of a sugar-containing organic material into a desired biochemical product. Use of a plurality of substrate-selective cells allows different sugars in a complex mixture to be consumed concurrently and independently. The method can be readily extended to remove inhibitory compounds from hydrolysate.

Substrate-selective co-fermentation process

Microbial production of pyruvate and metabolites derived from pyruvate in cells exhibiting reduced pyruvate dehydrogenase activity compared to wild-type cells. Acetate and glucose are supplied as a carbon sources.

Microbial production of pyruvate and other metabolites

Biological method for conversion of a lignocellulosic hydrolysate into a desired biochemical product. Use of a plurality of substrate-selective cells allows different sugars in a complex mixture to be consumed concurrently and independently. The method can be readily extended to remove inhibitory compounds from hydrolysate.

Growing community of inventors

Athens, GA, United States of America

Elliot Altman