Roche Diagnostics Gmbh

Ellen Moessner

Helmut Lenz

Gunter Pappert

Norbert Franken

Heinz Bodenmueller

Apostolos Kyriatsoulis

Michael Rottmann

Sabine Nussbaum

Gerald Praast

The invention concerns calibrators or calibration solutions which are based on a human serum matrix and which are used in a method for detecting cytokeratin, a process for producing them, a method for stabilizing cytokeratin and an immunological method for detecting cytokeratin in a sample.

Stabilization of calibrators containing cytokeratin

The invention concerns an immunological process for the detection of an analyte in a sample, in particular of tumor markers wherein for the reduction of interference substances containing a peptide sequence derived from the framework regions of the variable domain of the antibodies to be detected or the antibodies used for immune therapy or scintigraphy are added to the test preparation. Furthermore, the invention concerns the use of such substances for the reduction of interference of immunoassays, a suppressive agent and a process for the reduction of interference of immunoassays by the substances mentioned.

Reduction of interference of immunoassays by substances derived from the framework regions of antibodies

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Buehlerzell, Germany

Ellen Moessner