University of California

Massachusetts Institute of Technology

Ellen May Sletten

Carolyn Ruth Bertozzi

Timothy Manning Swager

Jennifer A Prescher

Jeremy Michael Baskin

Nicholas J Agard

Julia Ann Kalow

Lauren Dell Zarzar

Vishnu Sresht

Edmundo Daniel Blankschtein

Vladimir Bulovic

Jeffrey Hastings Lang

Farnaz Niroui

John C Jewett

Chelsea Gloria Gordon

Hae-Seung Harry Lee

Apoorva Murarka

Trisha L Andrew

Annie I-Jen Wang

Justin Caram

John O Chapman

Parag Deotare

Joseph A Jaye

Paresh Agarwal

Matthew Eric D'Asaro

Daniel A Estabrook

Emily D Cosco

Disclosed herein are amphiphilic polymers and hierarchical structures (e.g., emulsions) comprising said polymer. Also disclosed herein are methods of using the polymers and hierarchical structure disclosed herein.

Compositions and methods for cellular delivery

The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).

Compositions and methods for modification of biomolecules

Near infrared and shortwave infrared dyes can have polymethine structures.

Near and shortwave infrared polymethine dyes

The present disclosure provides tunable fluoropolymers and methods for making them.

Tunable linear fluoropolymers

The present disclosure provides SWIR-active small molecule polymethine dyes with improved properties for use in optical imaging, photothermal therapy, photodynamic therapy, and SWIR-promoted drug delivery.

Heterocyclyl polymethine IR chromophores

The present invention generally relates to compositions and methods for forming droplets and/or emulsions. In some embodiments, the compositions and methods comprise two or more components miscible at a first temperature and immiscible at a second temperature, dispersed in an outer phase.

Compositions and methods for forming emulsions

Devices comprising at least two electrodes with a layer disposed therebetween are disclosed. In some embodiments, the layer disposed therebetween may be an insulator. In some embodiments, the layer may be capable of being deformed. Deforming the layer may cause a change in one or more materials properties of the device, such as the electrical properties and/or the optical properties of the device.

Tunneling nanomechanical switches and tunable plasmonic nanogaps

The present disclosure features a strain-promoted [2+2+2] reaction that can be carried out under physiological conditions. In general, the reaction involves reacting a pi-electrophile with a low lying LUMO with a quadricyclane on a biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo and in vitro. The reaction is compatible with modification of living cells. In certain embodiments, the pi-electrophile can comprise a molecule of interest that is desired for delivery to a quadricyclane-containing biomolecule via [2+2+2] reaction.

Compositions and methods for quadricyclane modification of biomolecules

The present invention generally relates to colloids and methods for changing the arrangement of droplet phases. In some embodiments, the colloids and methods comprise a plurality of droplets comprising two or more components, such that the two or more components can change arrangement of the components in the presence of an external stimulus. In some embodiments, the change in component arrangement is reversible. In certain embodiments, the change in component arrangement forms Janus droplets.

Compositions and methods for arranging colloid phases

Electromechanical devices described herein may employ tunneling phenomena to function as low-voltage switches. Opposing electrodes may be separated by an elastically deformable layer which, in some cases, may be made up of a non-electrically conductive material. In some embodiments, the elastically deformable layer is substantially free of electrically conductive material. When a sufficient actuation voltage and/or force is applied, the electrodes are brought toward one another and, accordingly, the elastically deformable layer is compressed. Though, the elastically deformable layer prevents the electrodes from making direct contact with one another. Rather, when the electrodes are close enough to one another, a tunneling current arises therebetween. The elastically deformable layer may exhibit spring-like behavior such that, upon release of the actuation voltage and/or force, the separation distance between electrodes is restored. Thus, the electromechanical device may be actuated between open and closed switch positions.

Electromechanical device

Aldehyde- and ketone-functionalized proteins are promising new substrates for the development of chemically modified biotherapeutics and protein-based materials. Their reactive carbonyl groups are typically conjugated with a-effect nucleophiles, such as substituted hydrazines and alkoxyamines, to generate hydrazones and oximes, respectively. However, the resulting C&#x2550;N linkages are susceptible to hydrolysis under physiologically relevant conditions, which limits their utility in biological systems. Here we introduce a Pictet-Spengler ligation that is based on the classic Pictet-Spengler reaction of aldehydes and tryptamine nucleophiles. The ligation exploits the bioorthogonal reaction of aldehydes and alkoxyamines to form an intermediate oxyiminium ion; this intermediate undergoes intramolecular C&#x2014;C bond formation with an indole nucleophile to form an oxacarboline product that is hydrolytically stable. The reaction was utilized for site-specific chemical modification of glyoxal- and formylglycine-functionalized proteins, including an aldehyde-tagged variant of the therapeutic monoclonal antibody Herceptin. In conjunction with techniques for site-specific introduction of aldehydes into proteins, the Pictet-Spengler ligation offers a new means to generate stable bioconjugates for medical and materials applications.

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Berkeley, CA, United States of America

Ellen May Sletten