Warner-lambert Company

Ellen M Berman

Leslie M Werbel

Mark J Suto

Dennis Joseph McNamara

Edward Faith Elslager

Howard D Showalter

Daniel Fred Ortwine

Anthony Denver Sercel

David B Capps

Donald F Worth

Vlad E Gregor

Novel 6-substituted-4(3H)-quinazolinones are described as well as methods for the preparation and pharmaceutical composition of same, which inhabit the enzyme thymidylate synthase (TS) and are thus useful as anticancer agents.

Substituted quinazolinones as anticancer agents

An improved process for the preparation of 6-substituted-5-alkyl-2,4-quinazolinediamines, useful in the production of trimetrexate and similar antifolate agents, together with several novel intermediates are disclosed.

Substituted benzonitriles

Substituted 2H-[1]benzopyrano[4,3,2-cd]indazoles, 2H-[1]benzothiopyrano[4,3,2-cd]indazoles, and 2H-[1]benzoselenino[4,3,2-cd]indazoles have demonstrated pharmacological activity against a broad spectrum of Gram-positive and Gram-negative bacteria, yeasts, and fungi, as well as activity against the L1210 and P388 murine leukemia cells lines. Pharmaceutical compositions containing the compounds and methods of employing the compounds in methods of treating bacterial or fungal infections and of inhibiting the growth of neoplasms in mammals are also disclosed.

Antibacterial benzo(chalcogeno)[4,3,2-cd]indazoles

Growing community of inventors

Ann Arbor, MI, United States of America

Ellen M Berman