University of Michigan

Stel Technologies, LLC

Ellen M Arruda

Lisa M Larkin

Michael J Smietana

Michael D Thouless

Anthony M Waas

Tanaz Rahimzadeh

Pablo Moncada-Larrotiz

Nicholas Alexander Kotov

Robert G Dennis

Asheesh Bedi

Fatima N Syed-Picard

Jinjin Ma

Sarah C Calve

Levon Cimonian

Marie Rice

Stoyna Novakova

Paul Podsiadlo

Paul E Kosnik

Ravi K Birla

Aaron Adams

Keqin Cao

Leah Hatch-Vallier

Carlos A Pons Siepermann

Bong Sup Shim

Ryan M Anderson

Tatiana Y Kostriminova

Marvin O Boluyl

Keith R Baar

Gregory H Borschel

Pablo Moncado-larrotiz

Ming Yang

Jennifer Baltich

Haley Titinger

Michael Smietana

Michael Thouless

A bioreactor capable of producing complex, three-dimensional tissue constructs has improved media transfer and increased controllability with regard to exposure to the external environment. The bioreactor includes an external surface, a first tissue culture side for culturing a first cell source in a first tissue culture support region, a second tissue culture side for culturing a second cell source in a second tissue culture support region, and a plurality of ports. At least one of the ports of the plurality of ports extend from the first tissue culture support region of the first tissue culture side to the external surface. The plurality of ports can include an external port that is configured to be a liquid inlet when the bioreactor is in a first orientation and a gas outlet when the bioreactor is in a second orientation.

Bioreactor assembly, bioreactor, and method of operating same

The present disclosure relates to tissue engineering, and more particularly to a method for treating or repairing rotator cuff or other tendon tears or damage using scaffold-free, 3-dimensional engineered tendon constructs.

Engineered tendon graft for rotator cuff repair

A bioreactor and method of forming complex three-dimensional tissue constructs in a single culture chamber. The bioreactor and methods may be used to form multi-phasic tissue constructs having tissue formed from multiple cell types in a single culture chamber. The bioreactor includes at least one translation mechanism to facilitate translation of one or more tissue constructs without direct user intervention, thereby providing a closed, sterile environment for complex tissue fabrication. The bioreactor may be used as a stand-alone device or as part of a large-scale system including many bioreactors. The large-scale system may include a perfusion system to monitor and regulate the tissue culture environment.

Bioreactor and method of forming complex three-dimensional tissue constructs

The present disclosure relates to tissue engineering, and more particularly to a method for treating or repairing rotator cuff or other tendon tears or damage using scaffold-free 3-dimensional engineered tendon constructs.

Dissociation of a macroscale version of an aramid fiber leads to the nanofiber form of this polymer. Indefinitely stable dispersions of uniform high-aspect-ratio aramid nanofibers (ANFs) with diameters between 3 and 30 nm controlled by the media composition and up to 10 &#x3bc;m in length are obtained. ANFs can be processed in transparent thin films using layer-by-layer assembly (LBL) with superior mechanical performance.

Synthesis and use of aramid nanofibers

A protective device and method of design to protect against multiple blast and impact events for use in any application in which a delicate target has to be protected. The protective device for mitigating the effects of blast or impact employs a first layer having a first acoustic impedance and a second layer having a second acoustic impedance. The second acoustic impedance is different than the first acoustic impedance. The second layer is proximate to the first layer. The first layer and the second layer are chosen collectively to tune the stress waves from the blast or impact events to one or more specific tuned frequencies. A third layer of a visco-elastic material is employed having a critical damping frequency that matches one or more specific tuned frequencies to dissipate the stress waves of the blast and impact event. The third layer is proximate to the second layer.

Blast/impact frequency tuning mitigation

A tuning and mitigation system and method for mitigating a blast or impact event having an elastic layer having an acoustic impedance chosen to tune stress waves resulting from the blast or impact to one or more specific tuned frequencies, and a dissipative layer made of a viscoelastic material having a critical damping frequency that matches at least one or more specific tuned frequencies.

Blast/impact frequency tuning and mitigation

A tuning and mitigation system for mitigating a blast or impact event having a tuning layer assembly having an acoustic impedance chosen to tune stress waves resulting from the blast or impact to one or more specific tuned frequencies, and a dissipative layer assembly made of a viscoelastic material having a critical damping frequency that matches at least one or more specific tuned frequencies.

The invention relates to scaffold-free three dimensional nerve fibroblast constructs and method of generating the nerve fibroblast constructs. The invention also relates to methods or repairing nerve transection and replacing damaged nerve tissue using the nerve fibroblast constructs of the invention.

Scaffold-free three dimensional nerve fibroblast constructs

A system and method for forming a bone construct include providing bone marrow stromal cells on a substrate without disposing the cells within an exogenous scaffold, and culturing the cells in vitro in osteogenic media such that the cells form a confluent monolayer and detach from the substrate to form a self-organized three-dimensional bone construct. A system and method for forming a ligament construct using fibrogenic media and a system and method for forming a functionally integrated bone-ligament construct are also provided.

System and method for forming bone, ligament, and bone-ligament constructs

A stiff layered polymer nanocomposite comprising a substrate adapted to receive a plurality of alternating layers of a first material and a second material; wherein the first material and second material are a polyelectrolyte, an organic polymer or an inorganic colloid and said first material and said second material have a chemical affinity for each other, said plurality of layers crosslinked using a chemical or physical crosslinking agent. Thin films that are consolidated and optionally crosslinked can be manufactured into hierarchical laminates with rigid and stress resistant properties.

Ultrastrong and stiff layered polymer nanocomposites and hierarchical laminate materials thereof

Growing community of inventors

Ann Arbor, MI, United States of America

Ellen M Arruda