University of Georgia Research Foundation, Inc.

Alliance for Sustainable Energy, LLC

Triad National Security, LLC

Ellen Lee Neidle

Gregg Tyler Beckham

Christopher W Johnson

Mark Andrew Eiteman

Jeffrey G Linger

Ramesh K Jha

Isabel Pardo Mendoza

Taraka Dale

Alaa Ashraf Mahmoud Ahmed

Ryan E Bermel

Melissa Tumen-Velasquez

Biosensors for detection terephthalic acid (TPA) and methods of their use are provided. The biosensors include a nucleic acid encoding a TphR protein, a promoter regulated by TPA, and a reporter operably linked to the promoter. Vectors and host cells including the biosensors are also provided.

Terephthalate biosensors and uses thereof

The present disclosure relates to a non-naturally occurring microorganism that includes a gene encoding a MucK transporter protein, where the microorganism is capable of catabolizing terephthalic acid (TPA). In some embodiments of the present disclosure, the gene encoding the MucK transporter protein may contain at least one mutation, relative to a reference gene encoding a reference MucK transporter protein.

Mutant transporters for bacterial uptake of terephthalic acid

Disclosed herein are enzymes useful for the dealkylation of aromatic substrates, including the conversion of guaiacol or guaethol to catechol. Methods of converting aromatic substrates found in lignin-based feedstocks such as pyrolysis oil into products such as catechol are also disclosed. Also presented herein are methods for rapidly evolving and optimizing genetic regions.

Chimeric enzymes for conversion of lignin-derived chemicals

Growing community of inventors

Dacula, GA, United States of America

Ellen Lee Neidle