Lonza Inc.

Lonza Ag

Ellen Klegraf

Paul Hanselmann

Wilhelm Quittmann

Stephan Elzner

Wolfgang Wenger

Manuela Avi

Daniel Friedrich Fischer

Thomas Grützner

Jan Keller

Stefan Elzner

Subject of the invention is a process for the production of L-carnitine, wherein a &#x3b2;-lactone, which is a 4-(halomethyl)oxetane-2-one, is converted into L-carnitine, wherein the process comprises an enzymatic conversion of the &#x3b2;-lactone into (R)-4-halo-3-hydroxybutyric acid or (R)-4-halo-3-hydroxybutyric acid ester.

Process for the enzymatic production of carnitine from beta-lactones

The invention relates to a method for the production of L-carnitine, wherein a &#x3b2;-lactone, which is a 4-(halomethyl)oxetane-2-one, is converted into carnitine with trimethylamine (TMA), wherein the &#x3b2;-lactone is not subjected to a basic hydrolysis step before being contacted with the trimethylamine. The invention also relates to a carnitine having a unique impurity profile.

Process for the production of carnitine from &#x3b2;-lactones

The invention relates to process for the continuous production of 4-chloroacetoacetyl chloride, comprising the steps of (a) feeding diketene and chlorine into a thin film reactor and (b) reacting the diketene and chlorine to obtain 4-chloroacetoacetyl chloride. The invention also relates to a process for the production of 4-chloroacetoaceticacid ester, 4-chloroacetoaceticacid amide or 4-chloroacetoaceticacid imide from 4-chloroacetoacetyl chloride obtained according to the inventive process.

Process for the production of 4-chloroacetoacetyl chloride, 4-chloroacetoacetic acid esters, amides and imides

The invention relates to a method for the production of L-carnitine, wherein a chiral &#x3b2;-lactone carnitine precursor is obtained by a [2+2] cycloaddition of ketene with an aldehyde X&#x2014;CH&#x2014;CHO, wherein X is selected from Cl, Br, I and trimethylamine, in the presence of a chiral catalyst.

Process for the production of carnitine by cycloaddition

Process for removing hydrogen cyanide from ethanedinitrile by contacting hydrogen cyanide-containing ethanedinitrile with an organic reagent under formation of a covalent bond.

Process for removing hydrogen cyanide from ethanedinitrile

The invention relates to a process for the preparation of ethanedinitrile, by reading hydrocyanic acid in the liquid phase with nitric acid in the presence of a cupric ion catalyst.

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Brig-Glis, Switzerland

Ellen Klegraf