Trellis Bioscience, Inc.

Trellis Rsv Holdings, Inc.

Tetragenetics, Inc.

Ellen J Collarini

Lawrence M Kauvar

Orit Foord

Bruce Alan Keyt

William Don Harriman

Gizette Sperinde

Hung Nguyen

Marjan Fatholahi

Remy Cromer

Hans De Haard

Paul A Colussi

Theodore G Clark

Lore Mariën

Ashot Papoyan

Yelena Bisharyan

Janna Bednenko

Joanna Cardarelli

Douglas Kahn

Bas Van Der Woning

Alka Agrawal

Anti-Kv1.3 antibodies (mAbs), particularly mAbs that specifically bind to Kv1.3 with high affinity and/or inhibit Kv1.3 function, are disclosed. The amino acid sequences of the CDRs of the light chains and the heavy chains, as well as consensus sequences for these CDRs, of these anti-Kv1.3 mAbs are provided. Additionally, canonical structures for CDRs in the VH and VL regions of anti-Kv1.3 antibodies are provided. The disclosure also provides nucleic acid molecules encoding the anti-Kv1.3 mAbs, expression vectors, host cells, methods for making the anti-Kv1.3 mAbs, and methods for expressing the anti-Kv1.3 mAbs. Finally, methods of using the anti-Kv1.3 mAbs as therapeutics, such as for preventing or treating an autoimmune disorder, are disclosed.

Anti-Kv1.3 antibodies, and methods of production and use thereof

Individual monoclonal antibodies and fragments that bind a conserved epitope of the G protein of RSV and which are minimally immunogenic when administered to a human subject, are useful in treating RSV infections.

Anti-RSV G protein antibodies

Recombinant materials and methods for producing antibodies that specifically bind heregulin-coupled HER3, at a site distinct from the heregulin binding site, are described. These antibodies are particularly useful in treating cancer that expresses HER3.

Antibodies immunoreactive with heregulin-coupled HER3

Antibodies which specifically bind heregulin-coupled HER3, at a site distinct from the heregulin binding site, are described. These antibodies are particularly useful in treating cancer.

New applications for the use of distinguishable particulate labels available in a variety of hues and sized in the submicron range are described. These applications include profiling of cellular components, obtaining secretion patterns, identifying a multiplicity of components in chromatographic or electrophoretic techniques and identification of desired immunoglobulin secreting cells.

Use of particulate labels in bioanalyte detection methods

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Oakland, CA, United States of America

Ellen J Collarini