The Wistar Institute

Northwestern University

Ellen Heber-Katz

Phillip Byron Messersmith

Iossif A Strehin

Bernhard Dietzschold

Methods and compositions are described for enhancing tissue regeneration or wound repair in a mammalian subject comprising a composition comprising (a) a proline hydroxylase inhibitor component or molecule that increases or upregulates HIF1a and (b) a carrier component comprising a hydrogel.

Epimorphic regeneration and related hydrogel delivery systems

Mice in which enhance wound healing occurs can be used to identify genes and gene products which are involved in enhanced wound healing in mammals, including humans. Methods and compositions for treating wounds, including central and peripheral nerve wounds, are also provided.

Compositions and methods for wound healing

Levels of thyroid hormone can be decreased in a mammal to increase healing of heart wounds. The increased wound healing includes rapid re-epithelialization and recovery of normal architecture and function relative to mammals who have not been treated according to the invention.

Methods and compositions for healing heart wounds

A novel method of presenting an immunogenic peptide to an antigen presenting cell (APC) of a mammalian host, in order to generate a T cell response protective against a virus, such as herpes or rabies virus, comprising administering an immunologically effective amount of (1) a peptide-fatty acid conjugate, the peptide having the amino acid sequence corresponding to the sequence of a fragment of a glycoprotein or protein of the virus which produces a T cell response or a synthetic replica thereof, (2) a liposome composition and (3) an adjuvant so that the peptide protrudes from the liposome and when the liposome fuses with the APC, the peptide remains bound to the cell surface of the APC membrane.

Growing community of inventors

Philadelphia, PA, United States of America

Ellen Heber-Katz