Bicycletx Limited

Ellen Gowans

Michael Skynner

Steven Stanway

Gemma Elizabeth Mudd

Liuhong Chen

Katerine Van Rietschoten

Michael Rigby

Amy Brown

Punit Seth

John Davis

Liudvikas Urbonas

Donatella Di Rienzo

Rama McCrory

Emma Murphy

Yuliya Demydchuk

Emma Mead

Mike Rigby

Paul Brennan

Tom Smith

The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to TfR1. The invention also relates to multimeric binding complexes which comprise at least two of said bicyclic peptide ligands. The invention also includes pharmaceutical compositions comprising said peptide ligands and multimeric binding complexes and the use of said peptide ligands, and multimeric binding complexes and pharmaceutical compositions in preventing, suppressing or treating a disease or disorder through TfR1 mediated delivery of a therapeutic agent.

Bicyclic peptide ligands specific for transferrin receptor 1 (TfR1)

The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to TREM2. The invention also relates to multimeric binding complexes which comprise at least two of said bicyclic peptide ligands. The invention also includes pharmaceutical compositions comprising said peptide ligands and multimeric binding complexes and the use of said peptide ligands, multimeric binding complexes and pharmaceutical compositions in preventing, suppressing or treating a disease or disorder mediated by TREM2.

Bicyclic peptide ligands specific for TREM2

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Cambridge, United Kingdom

Ellen Gowans