Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Bar-ilan University

Diab R&d 1

Ella Meltzer-Mats

Arie Lev Gruzman

Shlomo Sasson

Erol Cerasi

The present invention is directed to compounds such as: formula wherein linker is independently selected from the group consisting of &#x2014;S&#x2014;, &#x2014;S&#x2014;S&#x2014;, &#x2014;S&#x2014;(CH2)n-, &#x2014;NH&#x2014;, &#x2014;NH&#x2014;(CH2)n-, &#x2014;O&#x2014;, &#x2014;SO2-, arylene, heteroarylene; R1 is selected from the group consisting of straight or branched C4-C20 alkyl, straight or branched C4-C20 alkenyl, straight or branched C4-C20 alkynyl, each optionally interrupted with at least one NH, C5-C7 saturated cycloalkyl or heteroalkyl ring, C5-C12 aromatic or heteroaromatic ring, each optionally substituted with at least one group selected from &#x2014;COOH, &#x2014;NH2, C1-C8 alkoxy, C1-C5 amidyle, C1-C5 carboxyl, halogen; and R2 is independently selected from the group consisting of H, OH, SH, NH2, NO2, halogen, CN, C1-C8 alkoxy, C1-C5 carboxylic acid, straight or branched C1-C8 alkyl, straight or branched C2-C10 alkenyl, straight or branched C2-C12 alkynyl each optionally substituted by at least one substituent selected from the group consisting of C1-C5 alkoxy, C1-C5 carboxylic acid, OH, SH, NH2, halogen; and compositions for use in the treatment of diabetes and related disorders. 

Growing community of inventors

Rishon-LeZion, Israel

Ella Meltzer-Mats