Ludwig Institute for Cancer Research Limited

Cornell University

Memorial Sloan Kettering Cancer Center

Elke Jäger

Alexander Knuth

Lloyd J Old

Yao-tseng Chen

Matthew J Scanlan

Gerd J Ritter

Ali O Gure

Jan Wouter Drijfhout

Elisabeth Stockert

Dirk Jäger

The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.

Method for inducing cell lysis with immunogenic portions of NY-ESO-1 protein

Isolated nucleic acid molecules which encode immunogenic portions of NY-ESO-1 protein

The invention relates to antibodies which bind to the cancer associated antigen NY-ESO-1. Both polyclonal and monoclonal antibodies are part of the invention, as are chimeric forms of the antibodies, and binding portions of antibodies. Uses of these antibodies are described. Also described are truncated, recombinant forms of the cancer associated antigen.

Isolated nucleic acid molecules encoding ESO-1 peptides and uses thereof

The present invention provides methods and diagnostic kits for the detection of disease-specific antibodies in urine containing sample. The present invention is also directed toward methods for determining that a patient suffers from a disorder characterized by aberrant expression of a naturally occurring gene. Methods for monitoring the status of a disorder in a patient characterized by aberrant expression of a naturally occurring gene are also provided.

Methods for detection of disease-associated antibodies in urine

Isolated nucleic acid molecules which encode peptides which bind to MHC class II molecules, such as HLA-DR53

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Frankfurt am Main, Germany

Elke Jäger