Other

Ludwig Institute for Cancer Research Limited

Elke J&auml;ger

Lloyd J Old

Yao-tseng Chen

Elisabeth Stockert

Knuth Alexander

Matthew J Scanlan

Ali O Gure

Jan Wouter Drijfhout

Alexander Knuth

Solam Tsang

Gerd J Ritter

Michael Pfreundschuh

Ugur Sahin

Ozlem Tureci

Ali Gur&eacute;

The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.

Isolated peptides corresponding to amino acid sequences of NY-ESO-1, which bind to MHC Class I and MHC Class II molecules, and uses thereof

The invention relates to the isolation of a nucleic acid molecule which encodes a cancer associated antigen. Also a part of the invention is the antigen itself, and the uses of the nucleic acid molecule and the antigen, and peptides derived from it.

Isolated nucleic acid molecule encoding cancer associated antigen, the antigen itself, and uses thereof

The invention relates to antibodies which bind to the cancer associated antigen NY-ESO-1. Both polyclonal and monoclonal antibodies are part of the invention, as are chimeric forms of the antibodies, and binding portions of antibodies. Uses of these antibodies are described. Also described are truncated, recombinant forms of the cancer associated antigen.

Truncated forms of NY-ESO-1 protein

Antibodies which bind to NY-ESO-1 cancer associated proteins, and hybridomas which produce these antibodies

The invention relates to methods for determining tumor status by determining antibodies specific to NY-ESO-1 in patient samples. One can determine whether a cancerous condition is progressing, regressing, or remaining stable by determining antibodies against NY-ESO-1 in a patient sample, and comparing the value obtained to a prior value. When the tumor in question expresses NY-ESO-1, a change in this value is indicative of a change in status of the cancerous condition.

Method for determining status of a cancerous condition by determining antibodies to NY-ESO-1 in a patient sample

Growing community of inventors

Frankfurt am Main, Germany

Elke Jäger

Growing community of inventors

Frankfurt am Main, Germany

Elke J&auml;ger

Elke Jäger