University of Washington

The Provost, Fellows, Foundation Scholars, & the Other Members of Board, of the College of Holy and Undiv. Trinity of Queen Elizabeth Near Dublin

Elizabeth Ryan

Edward A Clark

Aaron Marshall

Kevin Draves

Elaine Kay

Brian Flood

Manual Salto-Tellez

Emma Creagh

Katarzyna Oficjalska

Glen Doherty

The invention provides novel dendritic cell-associated lectin-like (DCAL-1) molecules, compositions and therapeutic methods of use. In one aspect, the invention provides isolated nucleic acid molecules that are capable of remaining hybridized to SEQ ID NO:1 or SEQ ID NO:3, including nucleic acid molecules that encode DCAL-1 polypeptides. In another aspect, the invention provides DCAL-1 polypeptides and portions thereof which are useful to stimulate T cell proliferation. In another aspect, the invention provides antibodies that specifically bind to DCAL-1 which are useful for promoting maturation of dendritic cells and for stimulating an immune response in vivo. In another aspect the invention provides methods of stimulating an immune response in an animal comprising introducing into the animal an anti-DCAL-1 antibody of the invention.

Dendritic cell-associated lectin-like molecules, compositions and methods of use

Growing community of inventors

Cappawhite, Ireland

Elizabeth Ryan