N.v. Organon

Msd Oss B.v.

Elizabeth Margaret Moir

Craig Jamieson

John Kinnaird Ferguson MacLean

Zoran Rankovic

Amanda Jane Lyons

Kevin James Gillen

Michael Gerard Gallagher

John Kinnaird Ferguson Maclean

The present invention relates to a heterocyclic derivative according to formula I wherein the variables are defined as in the specification, or to a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to a pharmaceutical composition comprising said heterocyclic derivatives and to their use in therapy, for instance in the treatment or prevention of psychiatric diseases where an enhancement of synaptic responses mediated by AMPA receptors is required, including schizophrenia, depression and learning and memory disorders such as Alzheimer's disease.

Substituted thieno[2,3-d]pyrimidines as AMPA modulators

The present invention relates to a heterocyclic derivative according to formula I wherein the variables are defined as in the specification, or to a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to a pharmaceutical composition comprising said heterocyclic derivatives and to their use in therapy, for instance in the treatment or prevention of psychiatric diseases where an enhancement of synaptic responses mediated by AMPA receptors is required, including schizophrenia, depression and Alzheimer's disease.

Heterocyclic derivatives

Growing community of inventors

Newhouse, United Kingdom

Elizabeth Margaret Moir