Oklahoma State University

Board of Regents for the Oklahoma Agricultural & Mechanical Colleges

Elizabeth M Holt

Kenneth D Berlin

Benjamin J Scherlag

Warren T Ford

Mark D Thompson

Bruce R Bailey, Iii

Novel heteroarotinoid compositions characterized by the formulae: ##STR1## where R is H, CH.sub.3 or C.sub.2 H.sub.5 and X is S, S O, O, NCH.sub.3, Si(CH.sub.3).sub.2, N.sup.+ (H)CH.sub.3 [Cl.sup.- ], N.sup.+ (H)CH.sub.3 [Br.sup.- ] or N.sup.+ (alkyl) CH.sub.3 [Cl.sup.- or Br.sup.-) where alkyl is CH.sub.3, C.sub.2 H.sub.5, CH.sub.2 .dbd.CHCH.sub.2 or C.sub.6 H.sub.5 CH.sub.2. Such compositions exhibit activity as anticancer agents.

Heteroarotinoid compounds as anticancer agents

3-Thia-7-azabicyclo(3.3.1)nonanes and derivatives thereof are disclosed. The preparation of these compounds is given. Their use as antiarrhythmic agents is given.

3-thia-7-azabicyclo(3.3.l)nonanes and derivatives as antiarrhythmic

Growing community of inventors

Stillwater, OK, United States of America

Elizabeth M Holt