Smithkline Beecham Corporation

Other

Replidyne, Inc.

Elizabeth Jane Lawlor

John Edward Hodgson

James Raymond Brown

Raymond Winfield Reichard

Andrew P Fosberry

Richard Oakley Nicholas

Daniel Robert Gentry

Min Wang

Michael Terence Black

Deborah Dee Jaworski

Rebecca Claire Greenwood

Richard Lloyd Warren

Magdalena Zalacain

Sanjoy Biswas

Ceri John Lewis

Martin M Rosenberg

Martin Karl Russel Burnham

Christopher Michael Traini

Judith M Ward

Christine Marie Debouck

Jeffrey L Mooney

Yi Yi Zhong

David John Holmes

Julie M Pratt

David Justin Charles Knowles

Lisa Kathleen Shilling

Karen Anne Ingraham

John Peter Throup

Alison Frances Chalker

Martin Karl Burnham

Damien McDevitt

John E Hodgson

Tong Li

Martin K R Burnham

Lisa Kathleen Katz

James N Brown

The invention provides metS polypeptides and DNA (RNA) encoding metS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing metS polypeptides to screen for antibacterial compounds.

Methionyl tRNA synthetase polynucleotides

The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.

tRNA synthetase

The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.

Peptidyl t-RNA hydrolase (PTH)

The invention provides methionyl tRNA synthetase (tRS) enzymes fromand methods of producing such tRS by recombinant techniques. Also provided are methods for utilizing tRS for the protection against infection, particularly bacterial infection, most particularlyinfection.

Methionyl tRNA synthetase polypeptides from Staphylococcus aureus

The invention providesmethionyl tRNA synthetase polypeptides and DNA (RNA) encodingmethionyl tRNA synthetase polypeptides and methods for producing such poypeptides by recombinant techniques. Also provided are methods for utilizingmethionyl tRNA synthetase polypeptides for the protection against infection, particularly bacterial infections.

Polynucleotides encoding methionyl tRNA synthetase from Staphylococcus aureus, related products and methods

The invention provides clpL polypeptides and DNA (RNA) encoding clpL polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing polypeptides to screen for antibacterial compounds.

Member of ATP dependent protease family, clpL

The invention provides trpS polypeptides and DNA (RNA) encoding trpS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing trpS polypeptides to screen for antibacterial compounds.

TrpS

The invention provides alaS polypeptides and DNA (RNA) encoding alaS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing alaS polypeptides to screen for antibacterial compounds.

Alanyl tRNA synthetase from Streptococcus pneumoniae

Asparaginyl tRNA synthetase from Staphylococcus Aureus

spo-rel polypeptides and DNA (RNA) encoding such spo-rel and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such spo-rel for the treatment of infection, particularly bacterial infections. Antagonists against such spo-rel and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of spo-rel nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding the relA/spoT gene family and for detecting the polypeptide in a host.

Spo-rel

The invention provides ileS polypeptides and DNA (RNA) encoding ileS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ileS polypeptides to screen for antibacterial compounds.

IleS

Tryptophenyl tRNA synthetase from Streptococcus pneumoniae

SigB polypeptides and DNA (RNA) encoding such SigB and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such SigB for the treatment of infection, particularly bacterial infections. Antagonists against such SigB and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of SigB nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding SigB operon and for detecting the polypeptide in a host.

SigB

The invention provides lysS polypeptides and DNA (RNA) encoding lysS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing lysS polypeptides to screen for antibacterial compounds.

Compounds

Growing community of inventors

Malvern, PA, United States of America

Elizabeth Jane Lawlor