University of Michigan

Colorado State University Research Foundation

Henry Ford Health System

Elizabeth Goldstein

Gary J Fisher

Mark Monroe Banaszak Holl

Bradford Grant Orr

Clifford M Les

Ming Fang

Anthony Turner

Methods and systems for diagnosing a bone disease or other condition related to collagen in a subject are provided. These include providing a bone sample from the subject and determining a quantitative collagen morphology value of the bone sample. A reference value is provided from a non-affected control subject where the reference value is a quantitative collagen morphology value from the same type of bone sample obtained from a population of non-affected control subjects. The quantitative collagen morphology value of the subject's bone sample is compared to the reference value. If the collagen morphology value is altered versus the reference value, the subject is diagnosed as having a collagen related bone disease. The collagen morphology value can include mean fibril spacings and distributions of the fibril spacings taken from a subject's bone sample.

Collagen D-spacings in fibril bundles

Growing community of inventors

Ann Arbor, MI, United States of America

Elizabeth Goldstein