Other

Elizabeth Fowler

Billy Fred McCutchen

Bruce D Hammock

Rama M Belagaje

Susumu Maeda

Eliahu Zlotkin

A recombinant baculovirus is provided with a genetic coding sequence for the production of a foreign protein that is toxic to insects. Preferred are nuclear polyhedrosis viruses, with preferred embodiments having been constructed and expressed in insect cells: BmNPV.AaIT and AcNPV.AaIT. Both embodiments function in insect cells infected therewith so as to have the toxin AaIT (originating from the venom of the scorpion ) secreted. A clone designated (pCIB4223), which contains the signal sequence fused to the AaIT sequence, has been deposited with the American type culture collection and designated &ldquo;ATCC 40906.&rdquo;

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Durham, NC, United States of America

Elizabeth Fowler