The Charles Stark Draper Laboratory, Inc.

Elizabeth Ellen Marr

Joseph L Charest

Brett C Isenberg

Corin Williams

Else M Vedula

Ernest Kim Soonho

Morgan Pilkenton

Patrick Davis

The systems and methods of the present disclosure provide highly deformable porous membrane culture systems and actuation methods for studying the effects of biomedical stretch on cultured tissue. A well plate can include a well having a first opening configured to receive an insert coupled to a deformable membrane. The well plate can include a gasket positioned within the well and configured to create a seal between the insert and the well when the insert is positioned in the well. The well plate can include a chamber defined beneath the well, the chamber configured to receive fluid media and to expose the fluid media to a surface of the deformable membrane when the insert is positioned in the well. The well plate can include an actuator configured to stretch the deformable membrane by a target amount of strain.

Highly deformable porous membrane culture system and actuation methods for studying the effects of biomechanical stretch on cultured tissue

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Brookline, MA, United States of America

Elizabeth Ellen Marr