Bristol-myers Squibb Pharma Company

Bristol-myers Squibb Compnay

Elizabeth C Arner

Micky Daniel Tortorella

Robert A Copeland

Ruiqin Liu

Michael A Pratta

Carl P Decicco

Timothy C Burn

Ronald L Magolda

James M Trzaskos

Fude Yang

Kimberly A Solomon

Jeffrey Allan Miller

Gary L Davis

This invention is directed to assays to determine the presence or absence of proteins that exhibit aggrecanase or ADMP activity. This invention also relates to peptides that acts as a substrates for ADMPs, their use in various assays to determine the presence or absence of ADMP activity, and their use as inhibitors of ADMP activity.

Assays and peptide substrate for determining aggrecan degrading metallo protease activity

The invention is directed to the family of aggrecan degrading metallo proteases (ADMPs) that exhibit the ability to cleave the aggrecan core protein between amino acid residues Glu-Ala. The invention encompasses the nucleic acids encoding such enzymes, processes for production of recombinant ADMPs, compositions containing such enzymes, and the use of these enzymes in various assays and for the development of novel inhibitors for use as therapies for diseases involving aggrecanase-mediated degradation of cartilage or other aggrecanase-associated diseases.

Antibodies to aggrecan-degrading metalloprotease and diagnostic methods using same

The invention is directed to the family of aggrecan degrading metallo proteases (ADMPs) that exhibit the ability to cleave the aggrecan core protein between amino acid residues Glu -Ala . The invention encompasses the nucleic acids encoding such enzymes, processes for production of recombinant ADMPs, compositions containing such enzymes, and the use of these enzymes in various assays and for the development of novel inhibitors for use as therapies for diseases involving aggrecanase-mediated degradation of cartilage or other aggrecanase-associated diseases.

Aggrecan degrading metallo proteases

Nucleic acids encoding aggrecan degrading metallo proteases

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West Grove, PA, United States of America

Elizabeth C Arner