Agion Technologies L.l.c.

Biocoat, Inc.

Elizabeth A Pastecki

Jeffrey A Trogolo

John E Barry

James B Johnston

Elizabeth G Pervin

Mark Hyman

Amy Stahl

An article including a surface having a coating thereon, in which the coating includes a base coat, firmly adhered to the surface, and a hydrophilic, biocompatible top-coat. An antibiotic ceramic component is dispersed in one or both of the base coat and top-coat. Preferably, the ceramic component is dispersed in the base coat. In a preferred embodiment, the ceramic component is a zeolite with silver ions exchanged onto internal acidic sites of the zeolite, and the top-coat includes a polysaccharide, such as hyaluronan. The zeolite is highly effective in imparting anti-microbial character to the coating.

Bi-laminar, hyaluronan coatings with silver-based anti-microbial properties

A dental appliance, such as of the orthodontic type, to be placed in the mouth and having an inorganic antimicrobial agent on a surface, the agent preferably being a zeolite. The dental appliance may comprise metal or a polymer and the agent may be present in a coating that is applied to the surfaces of the appliance that are to be contacted by liquids or solids in the mouth. The appliance can be of a polymer resin or an elastomer incorporating the agent. A preferred antimicrobial agent is ceramic particles (e.g., zeolite particles) containing antimicrobial metal ions, e.g., silver ions, as the active agent.

Antimicrobial dental products

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Malden, MA, United States of America

Elizabeth A Pastecki