Consiglio Nazionale Delle Ricerche

Asta Medica, Aktiengesellschaft

Other

University of Nottingham

Colorobbia Italia S.p.a.

The University of Milan

L'urederra Fundacion Para El Desarrollo Tecnologico Y Social

Elisabetta Ranucci

Paolo Ferruti

Francesco Maria Veronese

Oddone Schiavon

Paolo Caliceti

Luciana Sartore

Roberta Cavalli

Maurizio Penco

Giovanni Baldi

Marco Bitossi

Francesco Trotta

Franco Innocenti

David Lembo

Alfredo Ricci

Mauro Comes Franchini

Fabio Bignotti

Daniele Bonacchi

Giada Lorenzi

Claudio Fernandez

Martin Garnett

Guanidine-based poly (amidoamine) polymers of formula (I): wherein n is an integer between 3 and 400; Ris H, Calkyl; or taken together with the N atoms to which is bound and Ris a piperazinic ring; Ris Calkylen; Ccycloalkylen; CH&#x2014;COOH, CH&#x2014;COOR, wherein R is Calkyl, phenyl or benzyl; Ris &#x2014;(CH)p-HN&#x2014;C(NH)&#x2550;NH, wherein p is an integer 1 to 6; for use as antiviral agents in the prevention and/or treatment of viral infections in a mammal, preferably a human subject.

Anti-viral agents and compositions thereof

There are described nanoparticles of magnetic metal oxides employable in constructs consisting in polymer particles possibly also incorporating pharmacologically active substances.

Magnetic nanoparticles for the application in hyperthermia, preparation thereof and use in constructs having a pharmacological application

The invention provides compositions comprising a polyamidoamine (PAA) polymer comprising a pendant disulphide, sulphydryl, or activated sulphydryl moiety, and methods for their manufacture. The invention extends to the use of such polyamidoamine polymers to form cross-linked compositions, and hydrogels comprising the same, and the use of such compositions in various biological and non-biological applications, such as the delivery of biomolecules to target sites, and for tracking fluid flows. The invention also provides carrier particles, which may be used to deliver biomolecules, and to methods of treatment. The invention also provides a fluid tracking system for monitoring fluid flow.

Polymer

Hyperbranched, water-soluble polymers, obtainable by Michael polyaddition of &#x3b1;-, &#x3b2;-, or &#x3b3;-cyclodextrins and amines to bisacrylamides.

Hyperbranched polymers based on cyclodextrins and poly (amidoamines) for the controlled release of insoluble drugs

The invention relates to block copolymers of general formula (I)

Copolymers with polyester polycarbonate blocks containing

High molecular weight polyesterpolycarbonates and the use thereof for

A water-soluble polyvinyl 5-membered lactam having a molecular weight ranging from about 1000 to about 20,000 and chain-terminated with a compound selected from the group consisting of compounds of the following formulas ##STR1## wherein R and R.sup.1 are C.sub.1 to C.sub.4 alkyl or substituted alkyl; n is 0 to 20; R.sup.II is ethylene; R.sup.III is C.sub.1 to C.sub.24 alkylene or substituted alkylene; and R.sup.IV is C.sub.1 to C.sub.4 alkyl or substituted alkyl; can be prepared by polymerizing an N-vinyl 5-membered lactam in a liquid solvent-chain terminator compound of the formula (I) or (II) in the presence of a free radical initiator. The lactam polymer so-obtained may be activated and grafted to (conjugated with) a drug or an enzyme to alter the properties thereof.

Chain-terminated N-vinyl lactam polymers and graft-copolymers and

Polymers of the monomer N-acryloylmorpholine having a single reactive moiety at one end of the polymer chain have the following structure: ##STR1## wherein --Z--X--Y is a polymer capping moiety, such as mercaptan, X represents a saturated residue of a linear or branched aliphatic series of the general structure --C.sub.r H.sub.2r -- in which r is an integer from 1 to about 12, Y is a reactive moiety and typically will be one of the reactive moieties commonly known in PEG chemistry, such as an --OH, --COOH, or --NH.sub.2 group, Z is a moiety that readily reacts to cap a polymer free radical, and n is an integer from about 6 to 280, which yields a number average molecular weight ('M.sub.n ') of from about 1,000 to 40,000. The monofunctional polymer is a suitable alternative to monofunctional PEG for modification of substances having biological and biotechnical applications.

Polymers of N-acryloylmorpholine activated at one end and conjugates

Polymers of the monomer N-acryloylmorpholine having a single reactive moiety at one end of the polymer chain have the following structure: ##STR1## wherein -Z-X-Y is a polymer capping moiety, such as mercaptan, X represents a saturated residue of a linear or branched aliphatic series of the general structure --C.sub.r H.sub.2r -- in which r is an integer from 1 to about 12, Y is a reactive moiety and typically will be one of the reactive moieties commonly known in PEG chemistry, such as an --OH, --COOH, or --NH.sub.2 group, Z is a moiety that readily reacts to cap a polymer free radical, and n is an integer from about 6 to 280, which yields a number average molecular weight ('M.sub.n ') of from about 1,000 to 40,000. The monofunctional polymer is a suitable alternative to monofunctional PEG for modification of substances having biological and biotechnical applications.

Growing community of inventors

Opera, Italy

Elisabetta Ranucci