Morphosys Ag

Gpc Biotech Ag

Elisabeth Thomassen-Wolf

Stefan Steidl

Robert Rauchenberger

Michael Tesar

Zoltan Nagy

Christoph Brunner

The present invention provides recombinant antigen-binding regions, antibodies and functional fragments thereof that are specific for GM-CSF, which plays an integral role in various disorders or conditions. These antibodies, accordingly, can be used to treat, for example, inflammatory diseases such as rheumatoid arthritis. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of GM-CSF in the progression of various disorders. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.

Nucleic acid encoding anti-GM-CSF antibodies

Methods of treatment using anti-GM-CSF antibodies

Anti-GM-CSF antibodies

Anti-GM-CSF antibodies and uses therefor

The present invention relates to polypeptide compositions which bind to cell surface epitopes and, in multivalent forms, cause or lead to the killing of cells including lymphoid tumor cells, and in the case of monovalent forms, cause immunosuppression or otherwise inhibit activation of lymphocytes. The invention further relates to nucleic acids encoding the polypeptides, methods for the production of the polypeptides, methods for killing cells, methods for immunosuppressing a patient, pharmaceutical, diagnostic and multivalent compositions and kits comprising the polypeptides and uses of the polypeptides.

Human polypeptides causing or leading to the killing of cells including lymphoid tumor cells

Growing community of inventors

Gauting, Germany

Elisabeth Thomassen-Wolf