Helmholtz Zentrum Munchen Deutsches Forschungszentrum Fur Gesundheit Und Umwelt

Gsf-forschungszentrum Fuer Umwelt Und Gesundheit Gmbh

Mayo Foundation for Medical Education and Research

Eberhard Karls Universitaet Tuebingen

Gsf-forschungszentrum Fur Umwelt Und Gesundheit, Gmbh

Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt Gmbh

Corimmun Gmbh

Eberhard-karls-universitat Tubingen

Elisabeth Kremmer

Juergen Haas

Stefanie Kliche

Thomas Meitinger

Tim Matthias Strom

Matthew J Farrer

Marius Ueffing

Mary M Hulihan

Ryan Uitti

Zibigniew Wszolek

Jennifer M Kachergus

Saskia Biskup

Christian Johannes Gloeckner

Thomas Gasser

Petra Herzig

Friedrich Asmus

Nadja Patenge

Alexander Zimprich

Sara J Lincoln

Claudiu Supuran

Reinhard Zeidler

Andreas Bültmann

Michael Stürzl

Meinrad Gawaz

Götz Münch

Heinz H&ouml;fler

Christoph Schuhmacher

Karl-Friedrich Becker

Manfred Eulitz

Clara Lubeseder-Martellato

Eric Guenzi

Andrew Flatley

Christina Battke

Michael Stuerzl

Christian J Gloeckner

Petra Leitner

The present invention relates to an antibody binding to a carbonic anhydrase, wherein the antibody comprises (a) the amino acid sequences SEQ ID NOS. 1 (CDR 1), 2 (CDR 2) and 3 (CDR 3) determining the CDRs of the Vregion, and the amino acid sequences SEQ ID NOS. 4 (CDR 1), 5 (CDR 2) and 6 (CDR 3) determining the CDRs of the Vregion; or (b) the amino acids sequences of (a), wherein at least one amino acid is conservatively substituted in any one of the amino acid sequences SEQ ID NOS. 1 to 6.

Antibody to a carbonic anhydrase

The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.

KASPP (LRRK2) gene, its production and use for the detection and treatment of neurodegenerative disorders

The present invention provides anti-thrombotic agents, methods for screening for said anti-thrombotics agents and methods of treating thrombotic and other cardiovascular disorders.

Antibodies which bind to epitopes of glycoprotein VI

A method for the identification and/or quantification of GBP-1 or fragments of this protein in the culture supernatant of a tissue sample, a body fluid sample or a sample from a cell culture supernatant is described.

Elisa method for the detection of guanylate binding protein 1 (gbp-1)

The present invention is directed to monoclonal antibodies capable of specifically binding to and recognizing an antigenic determinant (epitope) of the protein kaposin or a derivative thereof, hybridoma cell lines producing said monoclonal antibodies, diagnostic systems for the detection of the presence of a kaposin protein or a derivative thereof as well as antibodies directed against the kaposin protein or a derivative thereof, methods for detection of the expression of kaposin protein or a derivative thereof in a biological sample, methods for the detection of antibodies directed against kaposin protein or a derivative thereof, uses of the monoclonal antibodies provided according to the invention and uses of the kaposin protein or a derivative thereof, each in diagnostics and therapy.

Diagnostics and therapy of diseases associated with HHV-8 infections

The present invention is directed to monoclonal antibodies capable of specifically binding to and recognizing an antigenic determinant (epitope) of the protein kaposin or a derivative therof, hybridoma cell lines producing said monoclonal antibodies, diagnostic systems for the detection of the presence of a kaposin protein or a derivative thereof as well as antibodies directed against the kaposin protein or a derivative thereof, methods for detection of the expression of kaposin protein or a derivative thereof in a biological sample, methods for the detection of antibodies directed against kaposin protein or a derivative thereof, uses of the monoclonal antibodies provided according to the invention and uses of the kaposin protein or a derivative thereof, each in diagnostics and therapy.

The present invention describes monoclonal antibodies which are useful for the specific detection of diffuse gastric carcinoma. Further embodiments describe therapeutic and diagnostic means for the detection and for the therapy of diffuse gastric carcinomas.

Mutations of E cadherin as a basis for the diagnosis and therapy of human malignant tumors

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Freising, Germany

Elisabeth Kremmer