Institut National De La Sante Et De La Recherche Medicale

Assistance Publique-hopitaux De Paris

Other

L'assistance Publique--hospitaux De Paris

Elisabeth Andree Tournier-Lasserve

Anne Marie Joutel

Marie-Germaine Madeleine Bousser

Jean-François Bach

Sophie Laberge-Le-Couteulx

Pierre Labauge

Jean-Fran&ccedil;ois Bach

The invention concerns a method for diagnosing cavernous angiomas for detecting mutations in the Krit1 gene. More particularly, said detection is performed by using nucleotide sequences. The invention further concerns the use of the Krit1 gene for therapeutic purposes in the field of angiogenesis.

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The invention concerns the Notch3 gene and the corresponding protein, which are involved in CADASIL. The invention concerns, in particular, methods for demonstrating mutations in this gene, which are linked to the risk of developing CADASIL and related diseases.

Gene involved in CADASIL, method of diagnosis and therapeutic application

The invention concerns the Notch3 gene and the corresponding protein, which are involved in CADASIL. The invention concerns, in particular, methods for demonstrating mutations in this gene, which are linked to the risk of developing CADASIL. The invention also concerns models and products for treating CADASIL and related diseases.

Gene involved in cadasil, method of diagnosis and therapeutic application

Method for screening for familial hemiplegic migraine which comprises searching for the presence of a mutated gene responsible for familial hemiplegic migraine on the chromosome 19, in the region comprised between the microsatellites D19S216 and D19S215, of a family or of an at risk individual, including fetus.

Method for the screening of familial hemiplegic migraine (FHM)

Genotypic diagnosis of CADASIL for symptomatic or at risk individuals or fetuses belonging to a family suspected of being affected by CADASIL is carried out by detecting DNA polymorphisms genetically linked to the mutated gene responsible for CADASIL, these DNA polymorphisms being located in the genetic interval of the chromosome 19 flanked by the microsatellites D198221 and D19S215 and including these microsatellites.

Growing community of inventors

Paris, France

Elisabeth Andree Tournier-Lasserve