Cristalia Produtos Quimicos Farmaceuticos Ltda.

Elisa Mannochio De Souza Russo

Ogari De Castro Pacheco

Valter Freire Torres Russo

Valter Freiro Torres Russo

Roberto Takashi Sudo

Maria Dos Prazeres Barbalho Simonetti

The present invention describes new pharmaceutical compositions in treatment of skin and/or mucous injuries, new therapeutic use of compounds and use of compositions and compounds in treatment of injuries that involve skin and/or mucous, and/or therapies where regeneration or modelling of tissues growth is necessary. Particularly these pharmaceutical compositions are indicated for treatment of injuries caused by burns.

Pharmaceutical compositions for topical use in treatment of skin or mucous injuries

The present invention describes a method of separation of the enantiomers of N-(2,6-dimethylphenyl)-1-propyl-2-piperidinocarboxamide. Another object of the present invention refers to the enantiomeric manipulation of the enantiomers of N-(2,6-dimethylphenyl)-1-propyl-2-piperidinocarboxamide, in order to achiever compounds and pharmaceutical compositions presenting diverse enantiomeric excesses of (S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinocarboxamide, in order to quantify and determine the participation of (R)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinocarboxamide in the anesthetic and cardiotoxic effects. These compounds and compositions enantiomerically manipulated demonstrate to present a significant improvement in itsanesthetic properties, presenting a cardiotoxic profile equivalent to pure enantiomer, a (S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinocarboxamide. 

Non-racemic mixtures of (S) and (R) enantiomers of N-(2,6-dimethylphenyl)-1-propyl-2-piperidinocarboxamide; related processes and pharmaceutical compositions

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Sao Paulo, Brazil

Elisa Mannochio De Souza Russo