Universitá Degli Studi Di Torino

Universita Degli Studi Del Piemonte Orientale "amedeo Avogadro"

Universtà Degli Studi Di Torino

Kither Biotech Srl

Elisa Ciraolo

Emilio Hirsch

Guido Forni

Tracey Pirali

Gian Cesare Tron

Giovanni Sorba

Ubaldina Galli

Alberto Massarotti

Claudia Curcio

Compounds of Formula (I): able to inhibit kinase activity, in particular Phosphatidylinositol 3-Kinases activity. The disclosure also relates to the use of compounds of Formula (I) for treatment of pathological conditions associated to alterations in Phosphatidylinositol 3-Kinases activity. 

Quinolin-4 (1H)-one derivatives as inhibitors of phosphatidylinositol 3-kinases

We describe the use of PI3K&#x3b2; protein and/or its encoding gene for the screening for substances useful in the treatment of cancers, preferably breast cancers, as well as a method for the diagnosis of malignant cell growth comprising the measuring the expression of PI3K&#x3b2;. We also describe non-human transgenic animals as models for studying human pathologies, preferably breast cancer, being transgenic for having altered PI3K&#x3b2; and Neu-T expression.

Regulation of expression of PI3K&#x3b2; protein in tumors

Growing community of inventors

Turin, Italy

Elisa Ciraolo