N.v. Nutricia

Eline Marleen Van Der Beek

Günther Boehm

Robert Johan Joseph Hageman

Jan Knol

Marieke Abrahamse-Berkeveld

Gelske Speelmans

Antonie Van Baalen

Annemarie Oosting

Johannes Bernard Van Goudoever

Christopher Beermann

Martine Sandra Alles

Patrick Joseph Gerardus Hendrikus Kamphuis

Martine Groenendijk

Katrien Maria Jozefa Van Laere

Willem Ferdinand Nieuwenhuizen

Renate Maria Louise Zwijsen

Stefanie Schoen

Dennis Stanley Acton

Annemiek Lidewij Schipper

Jimmy David Bell

Akhtar Raish Oozeer

Nana Bartke

Hubertus Josephus Maria Van De Heijning

Maryam Rakhshandehroo

Anne-Marie Davila

Anniek Lidewij Schipper

Marieke Abrahamse-Berkenveld

Neena Modi

Inga Christiane Teller

Francina Dorothea Kodde

Maaike Hélène Oosterveer

Carolus Maria Johannes Leonardus Vereijken

Renate Maria Louise Zwijssen

Caroline DESCLÉE De Maredsous

Johannes Lambertus Maria Mensink

Kaouther Ben Amor

An early in life nutritional intervention with a lipid component having both large lipid globules with phospholipids and an increased amount of palmitic acid in the sn-2 position in triglycerides were found to improve the fatty acid composition of cell membranes, in particular brain membranes.

Nutritional composition for improving cell membranes

The present invention relates to infant formulas and follow-on formulas containing optimised amino acid profiles, in particular optimised amounts and/or ratios of phenylalanine. The formulas may contain intact proteins, hydrolysed proteins, protein fractions, free amino acids and/or a combination thereof selected based on their ability to provide the formula with an optimised amino acid profile. The present invention also relates to the administration of these formulas to infants in order to achieve balanced growth and/or development, for promoting, assisting or achieving balanced growth or development of the brain of an infant and/or the cognitive function of an infant, and may also assist in preventing or reducing the risk of obesity later in life.

Formulas comprising optimised amino acid profiles

The present invention relates to formulae for infants comprising large lipid globules and/or lipid globules with a coating of phospholipids for rendering the growth trajectory or body development during the first year of life more similar to that observed for human milk fed infants.

Infant formula with special lipid architecture for promoting healthy growth

The invention relates to nutritional compositions comprising specifically designed lipid globules that are especially suited for preterm infants, small for gestational age infants and infants with retarded growth due to physical or mental stress after birth, for promoting catch-up growth and/or for use in improving body composition, improving adipose tissue distribution, decreasing visceral adipose tissue based on body weight and/or on total adipose tissue, and/or decreasing the ratio visceral adipose tissue to subcutaneous adipose tissue, in such infants, and/or providing nutrition to such infants.

Lipid composition for improving body composition during catch-up growth

The present invention relates to infant nutrition, in particular to infant nutrition comprising special lipid globules for improvement of the fatty acid composition in brain membranes.

Infant nutrition for improving fatty acid composition of brain membranes

The present invention concerns an improved balance of the essential branched chain amino acids leucine, isoleucine and valine in infant formula.

Low protein infant formula with increased essential amino acids

The present invention relates to a nutritional composition for infants and/or toddlers comprising a lipid component which has a large lipid globule size. The composition can be used to prevent obesity and/or improve body composition later in life.

Nutritional compositions with lipid globules with a core comprising vegetable lipids and a coating comprising phospholipids or polar lipids

The present invention relates to a nutritional composition for infants and/or toddlers comprising a lipid component which has a lipid globules coated with polar lipids. The composition can be used to prevent obesity and/or improve body composition later in life.

Nutritional compositions with coated lipid globules

The invention relates to the use of specifically designed lipid component with optimal fatty acid profile, an enhanced portion of the palmitic acid residues in the sn-2 position and present as lipid globules with a phospholipid coating for an early in life diet for improving the development of a healthy body composition, in particular prevention of obesity, later in life.

Metabolic imprinting effects of specifically designed lipid component

The present invention relates to a nutritional composition for infants and/or toddlers comprising a lipid component which has a lipid globules coated with polar lipids. The composition can be used to prevent obesity and/or improve body composition later in life. Said liquid comprises 10-50 wt % vegetable liquids based on the dry weight of the composition, and (i) 0.5-20 wt % phospholipids based on total weight or (ii) 0.6-25 wt % of polar lipids based on total lipids, wherein polar lipids are the sum of phospholipids, glycosphingolipids and cholesterol, and said composition comprises lipid globules with a core comprising said vegetable lipids and a coating comprising said phospholipids or polar lipids.

The present invention relates to a nutritional composition for infants and/or toddlers comprising a lipid component which has a large lipid globule size. The composition can be used to prevent obesity and/or improve body composition later in life. Said lipid component comprises 10-50 wt % vegetable lipids, and the lipid globules have a volume-weighted diameter above 1.0 m and/or a diameter of 2-12 m in an amount of at least 45 vol %.

The present invention relates to human milk fortifiers comprising high protein content and long chain poly-unsaturated fatty acids. Use of such human milk fortifier improves the body adipose tissue distribution by increasing the subcutaneous adipose tissue mass, while at the same time not increasing visceral adipose tissue.

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Wageningen, Netherlands

Eline Marleen Van Der Beek