Abacus Diagnostica Oy

Elina Tienari

Harri Takalo

Jouko Kankare

The invention relates to a detectable molecule comprising a biospecific binding reactant attached to a luminescent lanthanide chelate comprising a lanthanide ion and a chelating ligand of the formula (I) wherein, RRare independently of each other selected from the group consisting of hydrogen, methyl, ethyl, &#x2014;COOH, &#x2014;COO&#x2014;, &#x2014;CHCOOH, &#x2014;CHCOO&#x2014;, hydroxyl or OR; Ris selected from the group consisting of &#x2014;CH, &#x2014;C(CH), &#x2014;C(CR), wherein Ris an alkyl with 1 to 6 carbon atoms, &#x2014;CHCOOH, &#x2014;CHCOO, and appropriate hexose residues; Ris a linker for coupling to a biospecific binding reactant selected from the group consisting of thiourea (&#x2014;NH&#x2014;CS&#x2014;NH&#x2014;), aminoacetamide (&#x2014;NH&#x2014;CO&#x2014;CH&#x2014;NH&#x2014;), amide (&#x2014;NH&#x2014;CO&#x2014; and &#x2014;CO&#x2014;NH&#x2014;), aliphatic thioether (&#x2014;S&#x2014;), disulfide (&#x2014;S&#x2014;S&#x2014;) and 6-substituted-1,3,5-triazine-2,4-diamine; and the lanthanide ion is selected from the group consisting of europium(III), terbium(III), dysprosium(III) and samarium(III). The invention also relates to corresponding lanthanide chelates. The invention further relates to the use of the detectable molecule of the invention.

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Espoo, Finland

Elina Tienari