Schering Corporation

Magatti, Charles V.

Doll, Ronald J.

Gold, Elijah H.

Neustadt, Bernard R.

Smith, Elizabeth M.

Elijah H Gold

Bernard R Neustadt

Wei K Chang

Elizabeth M Smith

Joel G Berger

Daniel M Solomon

Ronald J Doll

Charles V Magatti

John W Clader

Robert W Watkins

Chester Puchalski

James J Kaminski

Esther Babad

Arthur J Elliott

David Loebenberg

Konstaninos S Petrakis

Compounds of the formula ##STR1## useful as antihypertensive agents are disclosed.

Carboxyalkyl dipeptides

Disclosed are fused benzazepine compounds, pharmaceutical compositions including such compounds, methods of using such compounds, for example, in the treatment of psychoses and/or depression, and intermediates useful in the preparation of such compounds.

Fused benzazepines

Substituted 8-amino-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines useful in treating mental disorders and which have activities of prolonged duration are disclosed. Methods for preparing these compounds and methods for their use are also described.

1,2,4,5 tetrahydro benzazepine-3 compounds and antipsychotic use thereof

Fused benzazepines, compositions of, and medical use thereof

Compositions containing (-)-5-{(R)-1-Hydroxy-2[(R)-1-methyl-3-phenylpropyl)amino]ethyl}salicylamid e exhibit potent vasodilating .beta.-adrenergic blocking properties and are useful for the treatment of hypertension.

Treatment of hypertension

Novel phosphorous containing compounds and compositions containing said compounds inhibit the actions of enkephalinases in mammals. Methods for preparing said compounds and compositions and methods for their use to elicit analgesia and treat mental disorders are described. Useful intermediates for preparing the compounds are also described.

Phosphorus containing compounds as inhibitors of enkephalinases

The present invention relates to ophthalmological pharmaceutical compositions comprising (benzothiadiazine, benzamide and benzenesulfonyl)phenyl-substituted carboxyalkyl dipeptide compounds and to methods for using said composition in reducing intraocular pressure, e.g., in the treatment of glaucoma.

Antiglaucoma compositions and methods

Novel compounds with angiotensin-converting enzyme inhibitory activity are disclosed. Such compounds are useful in the treatment of cardiovascular disorders, especially hypertension and congestive heart failure, and are useful in the treatment of glaucoma. Also disclosed is a novel process for preparing intermediates useful in the preparation of the claimed compounds.

Preparation of angiotensin-converting enzyme inhibitors

The present invention relates to carboxyalkyl dipeptides which are inhibitors of angiotensin-converting enzyme and are useful as antihypertensive agents and in the treatment of congestive heart failure. The compounds of the present invention are compounds of the formulae ##STR1## and the pharmaceutically acceptable salts thereof, wherein R and R.sup.6 are the same or different and are hydroxy or lower alkoxy;

Carboxyalkyl dipeptides and medical use thereof in treating hypertension

Carboxyalkyl dipeptides and anti-hypertensive use thereof

(Benzothiadiazine, benzamido and benzenesulfonyl)phenyl-substituted carboxyalkyl dipeptide compounds are disclosed. Compounds of this invention are useful as antihypertensive agents.

Process for preparing a specific diastereomer of a monoamino

Novel compounds with angiotensin-converting enzyme inhibitory activity are disclosed. Such compounds are useful in the treatment of cardiovascular disorders, especially hypertension and congestive heart failure, and are useful in the treatment of glaucoma.

Growing community of inventors

West Orange, NJ, United States of America

Elijah H Gold