Opsanitx LLC

Cambridge Biotech Corporation

Elihu Young

Andrew H Segal

Cheryl I Murphy

The present invention provides a fusion polypeptide which can bind to a cell surface binding moiety (e.g., a carbohydrate) and serve as a ligand for a cell surface polypeptide, as well as a vector comprising a nucleic acid encoding for such a fusion polypeptide, and a host cell comprising such nucleic acid. The present invention also provides a composition comprising an antigen bearing target and such a fusion polypeptide, as well as a composition comprising a virus or a cell and such a fusion polypeptide. The present invention further relates to a method of modulating an immune response in an animal using such compositions.

Lectin compositions and methods for modulating an immune response to an antigen

The present invention also relates to a method of reducing metastases in a subject comprising administering to the subject a composition comprising a multifunctional molecule comprising a first part which is capable of binding to an antigen bearing target and a second part which is capable of binding to a cell.

The invention provides Baculovirus vectors comprised of a promoter upstream from a signal peptide. The Baculovirus vectors allow for the expression of a glycosylated protein in the late term of Baculovirus infection. Methods for the construction of such a Baculovirus vector are also provided. In addition, methods for producing large amounts of a desired glycosylated protein in the late term infection of Baculovirus infection are also provided.

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Sharon, MA, United States of America

Elihu Young