Regenosca Sa

Elif Vardar

Jeffrey Alan Hubbell

Jeffrey A Hubbell

Ganesh Vythilingam

Hans M Larsson

Kalitha Pinnagoda

Peter Frey

Eva-Maria Balet

The invention relates to methods for producing a polymeric scaffold for use in tissue engineering applications or soft tissue surgery, as well as to the produced scaffolds and an associated kit. The method features a first fast drying step of applying a mechanical compression on a polymeric gel layer and a second slow drying step of the gel up to reach a polymer mass fraction of at least 60% w/w in the final scaffold. The method allows the production of scaffolds with high regeneration and healing properties of a grafted tissue via host cell invasion and colonization, and a good suturability. These goals are achieved through the formation within the scaffold of a non-uniform architecture creating softer and stiffer areas, which is maintained even upon re-swelling of the scaffold upon hydration of the final dried product.

Non-uniformly stiff polymeric scaffolds and methods for producing thereof

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Lausanne, Switzerland

Elif Vardar