Tel Aviv University

Ramot University Authority for Applied Research and Industrial Development Limited

Sepal Pharma S.a.

Sepal Pharma Ltd.

Eliezer Flescher

Yoel Kashman

Max Herzberg

Dorit Reischer

Shiri Shimony

Orit Fingrut

Natalia Goldin

M Herzberg

The present invention relates to novel jasmonate derivatives, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for prevention and treatment of cancers.

Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof

The present invention provides compositions comprising compounds that selectively bind to hexokinases thereby promoting dissociation of these enzymes from mitochondria, and methods of use of such compounds and compositions to induce cell death in diseases and disorders characterized by the high levels of mitochondrial bound hexokinase. The present invention further discloses methods and assays for detecting and identifying molecules having these activities.

Jasmonate based assays for identifying compounds that selectively inhibit mitochondrial bound hexokinases

The present invention provides novel jasmonate derivative compounds, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for treatment of cancers, especially mammalian cancers.

Jasmonate derivative compounds pharmaceutical compounds and methods of use thereof

Jasmonate derivative compounds, pharmaceuticals compounds and methods of use thereof

Jasmonate pharmaceutical composition for treatment of cancer

Growing community of inventors

Hod Hasharon, Israel

Eliezer Flescher