Emd Millipore Corporation

Elias G Noukas

Brian Pereira

James A Austin

Dennis Wong

Boris Pesakovich

James Hobson

Thomas Janko

Shaun McMahon

Aaron Burke

Michael Felo

John Saragosa

Kristin Prescott

The present invention is an alignment device for a bag containing one or more ports. The alignment device is attached to either the one or more ports or to the bag adjacent the one or more ports. The plate has an indicator or a unique outer edge shape that is designed to fit into a corresponding unique opening in a holder to ensure proper alignment of the bag and its port(s) in the holder. The plate is has a series of holes equal to and in alignment with the one or more ports of the bag and the port(s) extend through the holes of the plate.

Disposable processing bag with alignment feature

A feed bag construction is provided comprising a feed bag, a first conduit sealed to the feed bag, a second conduit sealed to the interior of the feed bag for supplying wash reagent to the feed bag and a one piece cap that is removably mounted on the first conduit. The first conduit is provided with a hand operated butterfly valve to open or close the conduit.

Feed bag construction

An alignment device for a bag containing one or more ports wherein the alignment device is attached to the one or more ports or to the bag adjacent the one or more ports. The plate has either an indicator or a unique outer edge shape that is designed to fit into a corresponding unique opening in a bag holder to ensure proper alignment of the bag and its port(s) in the holder. In one embodiment the plate has a series of holes equal to and in alignment with the one or more ports of the bag and the port(s) are extended through the holes of the plate and the plate is attached to the bag by retainers on the port(s) below the plate. Alternatively, the plate may be fitted over the port(s) and attached to the bag.

The biocontainer of the present invention provides a low cost, simple solution of many of the problems encountered during shipping, freezing and thawing of biopharmaceutical materials. The present invention enables a user to monitor the temperature profile of each biopharmaceutical container during the cryogenic process, so as to ensure the integrity of materials within each biocontainer by using a pre-installed and pre-sterilized temperature sensor. In some embodiments, the sensor assembly includes a wireless transmitter and is capable of transmitting information regarding the measured reading. In other embodiments, the sensor assembly includes a processing unit, which determines whether the temperature profile is acceptable. In a further embodiment, an indicator is included, such that the processing unit may indicate whether the biopharmaceutical material has been properly frozen. In other embodiments, the sensor assembly also includes a storage element, which is capable of storing various parameters during the freezing process.

Biomaterial freezing

Biocontainer with integrated temperature sensor

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Burlington, MA, United States of America

Elias G Noukas