Centre National De La Recherche Scientifique

Centre De Recherches Biologiques Et D'experimentations Cutanees

Université Cergy-pontoise

Institut European De Biologic Cellulaire

Institut Francais Des Sciences Et Technologies Des Transports, De L'amenagement Et Des Reseaux

UniversitÉ De Cergy Pontoise

Conservatoire National Des Arts Et Metiers

Elian Lati

Michel Hocquaux

Joanna Bakala

Régis Besse

Stéphanie Almeida Épouse Scalvino

Jean-Yves Le Huerou

Stéphane Serfaty

Laurent Peno-Mazzarino

The object of the present invention relates to a novel family of peptide conjugates of formula (I):A-X-X-Pro-Ala-X&#x2014;B&#x2003;&#x2003;(I)

Peptides of use in the preventive and curative treatment of alopecia

The invention concerns a Thickness Shear Mode (TSM) biosensor () which comprises an ex vivo living skin explant (), the skin explant () comprising at least one of the skin layers among: hypodermis, dermis (A), epidermis (B) and the stratum corneum (C), a TSM transducer () which comprises: an AT cut quartz resonatorC which has two opposite exterior surfaces (A,B), and two conducting electrodes (A,B), each conducting electrode being deposited on one of the two exterior surfaces (A,B), the TSM transducer () allowing to determine micro rheological characteristics of the living skin explant () by piezoelectric transducing using shear waves, the TSM transducer () presenting: measuring means (), monitoring and calculating means () which monitor an evolution in time of an electrical response of the living skin explant (), and which calculate in time, from the electrical response, micro rheological characteristics of the living skin explant (), a bottom surface of the skin explant () being in contact with the TSM transducer (), a top surface of the skin explant () being in contact with air.

TSM biosensor to ex-vivo characterize the viscoelastic properties of skin

Growing community of inventors

Vanves, France

Elian Lati