University of Pittsburgh

Elia Beniash

Charles S Sfeir

Avinash Jagannath Patil

Avinash Patil

The invention relates to self-assembled organosilane- and small molecule drug-containing coatings for resorbable medical implant devices. The coatings can be prepared from precursor compositions containing an organosilane and a small molecule drug, and can be applied to substrates. Prior to applying the coatings, the surfaces of the substrates can be pretreated. The coatings can be functionalized with a binding compound that is coupled with an active component. The coatings can be applied using various techniques and apparatus, more particularly, by a deep-coating process conducted at ambient conditions.

Use of self-assembled alkylsilane coatings for drug delivery applications

The invention relates to self-assembled organosilane coatings for resorbable medical implant devices. The coatings can be prepared from coating compositions containing organosilane and can be applied to metal or metal alloy substrates. Prior to applying the coatings, the surfaces of the substrates can be pretreated. The coatings can be functionalized with a binding compound that is coupled with an active component. The coatings can be selectively removed, e.g., patterned, to expose portions of the uncoated substrate. Selecting different patterns can provide the ability to regulate or control various properties, such as, corrosion and hydrogen generation.

Systems and methods for selective coating removal for resorbable metal medical devices

The invention relates to peptides including DEDE(SSD)DEG indicated by SEQ NO. 1, RRRDEDE(SSD)DEG indicated by SEQ NO. 2, RRRGDEDE(SSD)DEG indicated by SEQ NO. 3, and LKKLKKLDEDE(SSD)nDEG indicated by SEQ NO. 4, wherein n is an integer from 2 to 20. The invention also relates to phosphorylating these peptides at multiple amino acid sites by employing casein kinases. These phosphorylated peptides may be used in various applications such as forming mineralized collagen fibrils and biomimetic composites for use in tissue repair and regeneration.

Bone substitute nanocomposites and methods of synthesis using multiphosphorylated peptides

The invention relates to biomimetic peptide-containing compositions for use, in particular, for application and or deposition on a magnesium alloy, e.g., substrate, to at least partially coat a surface of the magnesium alloy. The invention also relates to the coated magnesium alloy which is particularly useful for tissue and bone repair and regeneration applications, such as, for constructing medical implant devices.

Biomimetic coating of magnesium alloy for enhanced corrosion resistance and calcium phosphate deposition

The invention relates to peptides including DEDE(SSD)DEG indicated by SEQ NO. 1, RRRDEDE(SSD)DEG indicated by SEQ No. 2, RRRGDEDE(SSD)DEG indicated by SEQ No. 3, and LKKLKKLDEDE(SSD)nDEG indicated by SEQ NO. 4, wherein n is an integer from 2 to 20. The invention also relates to phosphorylating these peptides at multiple amino acid sites by employing casein kinases. These phosphorylated peptides may be used in various applications such as forming mineralized collagen fibrils and biomimetic composites for use in tissue repair and regeneration.

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Mt. Lebanon, PA, United States of America

Elia Beniash