Mesoscale Technologies, Llc.

Singular Genomics Systems, Inc.

The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc.

Groundmetrics, Inc.

Other

Meso Scale Diagnostics, LLC

Eli N Glezer

George B Sigal

Bandele J Jeffrey-Coker

Sudeep Kumar

Charles M Clinton

Sandor L Kovacs

Jeff D Debad

Daan Witters

Michael Tsionsky

Jonathan K Leland

Mark A Billadeau

Kent Johnson

Abrehet Abdu

Jacob N Wohlstadter

John H Kenten

Michael L Vock

Anson Hsu

Alan Kishbaugh

James L Wilbur

Cory Spivey

Hu Cang

Souad Naji

Carl C Stevens

Zhenmin Hong

Martin Stengelin

Yuji Ishitsuka

Alan B Fischer

Kenneth E Page

Joseph M Leginus

Anu Mathew

Martin Maria Fabani

Sriram Jambunathan

Mohammad Vatankhah Varnosfaderani

Koustubh A Phalnikar

David Marc Baranson

Allen Lipson

Sabrina Shore

Andrew Spaventa

Anahit Aghvanyan

Mark T Martin

Manish Kochar

Ronald J Graham

Aaron H Leimkuehler

Pankaj Oberoi

Larry Helms

Ian D Chamberlin

Jon S Willoughby

Zachary Terranova

Jeffery D Debad

Svetlana Leytner

Kristian Roth

Rodrigo Rodriguez

Megha Cila

Olga Adelfinskaya

Vahid Karimkhani

Youngjin Cho

Selen Stromgren

Timothy Looney

Fedor Trintchouk

Ryan Shultzaberger

Gisbert Spieles

Sharon West

Leo Tabakin

Carl W Fuller

Selen Altunata

Michael Warnock

D T Le

Natalia I Ossetrova

John Van Doorn

William F Blakely

Charles A Wijayawardhana

Kent Johhnson

Stephen Higgins

William Dempsey

Weiqiao Ding

Jaekyung Koh

David Routenberg

Lance Gordon Hussey

Niranjan Y Sardesai

Rodger Darin Osborne

Ravi Sawhney

Andrew Dennis Hibbs

Hans Biebuyck

Xinri Cong

Carl Edens

Hirotomi Teranishi

Gudrun Stengel

David L Barker

Robert M Umek

Paula Denney Eason

Nicholas Anderson

Noel Lawrence

Niek Van Wietmarschen

Shahed Kay

Galina Nikolenko

Brian A Self

Nasahn Sheppard

Chris Glupker

Michael Vock

John Mattson

The present invention is directed to methods for improving assay specificity and performance in binding assays.

Assay methods

Provided herein are methods including alternating series of sequencing cycles and dark extension cycles allowing longer read lengths and addressing disadvantages of traditional nucleic acid sequencing protocols.

Dark cycle sequencing

Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a sample comprising a cell.

Spatial sequencing of modified sequences

The present invention is directed to methods for reducing cross-reactivity between species employed in multiplexed immunoassays.

Co-binder assisted assay methods

Provided herein are modified Archaeal family B polymerases derived from species of the Archaeal microorganismthat exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.

Engineeredenzymes and uses thereof

Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.

Methods for diagnosing an inflammatory bowel disease based on soluble tumor necrosis factor II (sTNFRII) levels in a patient sample and treating thereafter

We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

Assay apparatuses, methods and reagents

Disclosed herein, inter alia, are devices and methods for transfer and analysis of tissue sections using carrier substrates.

Device for tissue section immobilization and retention

Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a cell.

In situ detection of nucleic acid molecules

Methods for in situ transcriptomics and proteomics

Disclosed herein, inter alia, are devices, compositions, kits, and methods for interrogating biological samples.

Multiomic analysis device and methods of use thereof

Microplate

A device comprising: a sample stage configured to be coupled to a microplate receiver; a microplate receiver configured to be coupled to a microplate; at least one heating element thermally coupled to the microplate receiver; a fluidics dispenser configured to dispense one or more reagents into the microplate; and an imaging system configured to detect one or more features in the microplate; and a structure physically coupled to the sample stage, the heating element, the fluidics dispenser, and the imaging system.

Microplate assembly

Growing community of inventors

Del Mar, CA, United States of America

Eli N Glezer