Singular Genomics Systems, Inc.

Mesoscale Technologies, Llc.

The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc.

Groundmetrics, Inc.

Other

Meso Scale Diagnostics, LLC

Sigal, George

Glezer, Eli N.

Eli N Glezer

Bandele J Jeffrey-Coker

George B Sigal

Sudeep Kumar

Sandor L Kovacs

Charles M Clinton

Daan Witters

Jeff D Debad

Michael Tsionsky

Jonathan K Leland

Mark A Billadeau

John H Kenten

Kent Johnson

Abrehet Abdu

Jacob N Wohlstadter

Anson Hsu

Michael L Vock

Alan Kishbaugh

Hu Cang

Cory Spivey

Souad Naji

James L Wilbur

Yuji Ishitsuka

Carl C Stevens

Mohammad Vatankhah Varnosfaderani

Zhenmin Hong

Martin Stengelin

Alan B Fischer

Kenneth E Page

Martin Maria Fabani

Allen Lipson

Joseph M Leginus

Anu Mathew

Andrew Spaventa

Sriram Jambunathan

Koustubh A Phalnikar

David Marc Baranson

Sabrina Shore

Anahit Aghvanyan

Mark T Martin

Manish Kochar

Ronald J Graham

Aaron H Leimkuehler

Pankaj Oberoi

Larry Helms

Jon S Willoughby

Ian D Chamberlin

Zachary Terranova

Jeffery D Debad

Vahid Karimkhani

Svetlana Leytner

Kristian Roth

Rodrigo Rodriguez

Megha Cila

Olga Adelfinskaya

Carl W Fuller

Christopher Frye

Youngjin Cho

Selen Stromgren

Timothy Looney

Fedor Trintchouk

Ryan Shultzaberger

Gisbert Spieles

Leo Tabakin

Sharon West

Selen Altunata

Michael Warnock

D T Le

Jaekyung Koh

Natalia I Ossetrova

John Van Doorn

William F Blakely

Charles A Wijayawardhana

Stephen Higgins

Kent Johhnson

William Dempsey

Weiqiao Ding

David Routenberg

Lance Gordon Hussey

Rodger Darin Osborne

Niranjan Y Sardesai

Ravi Sawhney

Andrew Dennis Hibbs

Hans Biebuyck

Xinri Cong

Carl Edens

Gudrun Stengel

Hirotomi Teranishi

David L Barker

Robert M Umek

Paula Denney Eason

Nicholas Anderson

Noel Lawrence

Niek Van Wietmarschen

Shahed Kay

Galina Nikolenko

David Louis Heiner

Tim Nugent

Chris Glupker

Fei Yin

Disclosed herein, inter alia, are novel methods pertaining to nucleic acid amplification and detection. Devices, compositions, and kits for use in such methods are also provided.

Chemical and thermal assisted nucleic acid amplification methods

Provided herein are methods and compositions for improved sequencing techniques using, for example, polymeric particles and/or three-dimensional structures.

Compositions and methods for nucleic acid sequencing

Microplate receiver frame

Provided herein are modified Archaeal family B polymerases derived from the Archaeal microorganismthat exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.

Modified archaeal family B polymerases

A multi-depth confocal imaging system includes at least one light source configured to provide excitation beams and an objective lens. The excitation beams are focused into a sample at a first plurality of focus depths along an excitation direction through the objective lens. An image sensor receives emissions from the sample via the objective lens, wherein the emissions define foci relative to the image sensor at a second plurality of focus depths.

Methods and systems for multidimensional imaging

Disclosed herein, inter alia, are devices, compositions, kits, and methods for interrogating biological samples.

Multiomic analysis device and methods of use thereof

Reagent cartridge

The present invention is directed to methods for improving assay specificity and performance in binding assays.

Assay methods

Provided herein are methods including alternating series of sequencing cycles and dark extension cycles allowing longer read lengths and addressing disadvantages of traditional nucleic acid sequencing protocols.

Dark cycle sequencing

Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a sample comprising a cell.

Spatial sequencing of modified sequences

The present invention is directed to methods for reducing cross-reactivity between species employed in multiplexed immunoassays.

Co-binder assisted assay methods

Provided herein are modified Archaeal family B polymerases derived from species of the Archaeal microorganismthat exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.

Engineeredenzymes and uses thereof

Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.

Methods for diagnosing an inflammatory bowel disease based on soluble tumor necrosis factor II (sTNFRII) levels in a patient sample and treating thereafter

We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

Assay apparatuses, methods and reagents

Disclosed herein, inter alia, are devices and methods for transfer and analysis of tissue sections using carrier substrates.

Device for tissue section immobilization and retention

Growing community of inventors

Del Mar, CA, United States of America

Eli N Glezer