Magnetecs Corporation

Neuro-kinesis Inc.

Baropace, Inc.

Eupalamus LLC

Eli Gang

Yehoshua Shachar

Laszlo Farkas

Josh Shachar

Leslie Farkas

Bruce Marx

Marc Rocklinger

Michael Burnam

David Johnson

H Stephen Cookston

John Wright

Doyoung Kim

A pacemaker control system includes a pacemaker; a plurality of sensors which are internal to the pacemaker, a plurality of sensors which are external to the pacemaker, a circuit for entering patient reports; and a circuit for using artificial intelligence to process outputs from the plurality sensors internal and external to the pacemaker and from the circuit for entering patient reports, which are collectively identified as a labeled dataset, to reiteratsvely learn a function which determines the labeled dataset most likely to provide optimal pacemaker function for the patient. The means for using artificial intelligence comprises a database of archive outputs from the plurality sensors internal and external to the pacemaker and from the means for entering patient reports for the patient used for optimization of rate modulation to intelligently, continuously and physiologically control the pacemaker.

Intelligently, continuously and physiologically controlled pacemaker and method of operation of the same

A method of right atrial pacing of a heart of a patient includes the steps of: stimulating right atrial tissue of the heart using a right atrial lead of a dual chamber cardiac pacemaker to pace the heart with a stimulus architecture protocol; and stimulating local sympathetic and/or parasympathetic tissues with the stimulus architecture protocol proximate to the paced right atrial tissue causing nervous system activity that inhibits the autonomous nervous system to reduce blood pressure. A closed loop system operating according to this method and a cardiac pacing lead for implementing this method also are included within the scope of the illustrated embodiments.

Method of treatment of drug resistant hypertension

A catheter is provided which exhibits higher resolution at its distal end. The higher resolution can be accomplished by combining and amplifying signals received at electrodes locally. These combined and amplified signals can then be digitized locally and transmitted for further processing. Optical communication channels may be used.

Catheter for cardiac and renal nerve sensing and mediation

The embodiments include an apparatus used in combination with a computer for sensing biopotentials. The apparatus includes a catheter in which there is a plurality of sensing electrodes, a corresponding plurality of local amplifiers, each coupled to one of the plurality of sensing electrodes, a data, control and power circuit coupled to the plurality of local amplifiers, and a photonic device bidirectionally communicating an electrical signal with the data, control and power circuit. An optical fiber optically communicated with the photonic device. The photonic device bidirectionally communicates an optical signal with the optical fiber. An optical interface device provides optical power to the optical fiber and thence to the photonic device and receives optical signals through the optical fiber from the photonic device. The optical interface device bidirectionally communicates an electrical data, control and power signal to the computer.

Optically coupled catheter and method of using the same

A system for a mapping and ablation catheter. The catheter includes a MOSFET sensor array that provides better fidelity of the signal measurements as well as data collection and reduces the error generated by spatial distribution of the isotropic and anisotropic wave fronts and error associated with near and far field's signal averages. The system maps the change in bioelectric potential in the vicinity of an activation wave front. During measurement, the manifold carrying the sensor array translates and rotates so as to achieve a measure of high potential employing an impedance value. The system of guiding and controlling the movement of the catheter distal end is able to deliver energy for ablating the renal artery nerve and thereby providing a safe and efficient method and apparatus for neuromodulation.

Method and apparatus for magnetically guided catheter for renal denervation employing MOSFET sensor array

This invention relates generally to electro-anatomical mapping method and an apparatus using a catheter and more particularly to a mapping catheter having an embedded MOSFET sensor array for detecting local electrophysiological parameters such as biopotential signals within an excitable cellular matrix geometry, for determining physiological as well as electrical characteristics of conduction path and its underlying substrate within the endocardial and epicardial spaces, the arterial structure and in ganglionic plexus. The apparatus with its MOSFET sensor is geometrically configured as a decapolar linear array and optionally with an 8&#xd7;8 sensor matrix placed on a balloon-like structure.

Method and apparatus for measuring biopotential and mapping ephaptic coupling employing a catheter with MOSFET sensor array

The invention relates to a method for using tissue contact technology to optimize automated cardiac chamber mapping algorithms to both speed up the mapping process and guarantee the definition of the actual chamber limits. The invention further comprises a method for conveying tissue type information to such automatic mapping algorithms so as to allow them to adapt their point collection density within areas of particular interest. The method is enhanced by the use of a magnetic chamber that employs electromagnetic coils configured as a waveguide that radiate magnetic fields by shaping the necessary flux density axis on and around the catheter distal tip so as to push, pull and rotate the tip on demand and as defined by such automatic mapping algorithms.

System and method for using tissue contact information in an automated mapping of cardiac chambers employing magnetically shaped fields

A tissue-contact seeking method and apparatus is described that enhances catheter position detection and control systems in making and maintaining continuous tissue contact in a highly dynamic frame, such as under the rigors of cardiac motion. Tissue-seeking logical routines use a tissue contact sensing system to advance a catheter to relatively continuous tissue contact, or detect obstacles, in cooperation with the catheter position detection and control systems. Additional logical routines are capable of optimizing the contact direction of the catheter tip by controlling the rotation angle and chamber position of the introducer.

System and method for a catheter impedance seeking device

A mapping and ablation catheter is described. In one embodiment, the catheter includes a MOSFET sensor array that provides better fidelity of the signal measurements as well as data collection and reduces the error generated by spatial distribution of the isotropic and anisotropic wavefronts. In one embodiment, the system maps the change in potential in the vicinity of an activation wavefront. In one embodiment, the mapping system tracks the spread of excitation in the heart, with properties such as propagation velocity changes. In one embodiment, during measurement, the manifold carrying the sensor array expands from a closed position state to a deployable open state. Spatial variation of the electrical potential is captured by the system's ability to occupy the same three-dimensional coordinate set for repeated measurements of the desired site. In one embodiment, an interpolation algorithm tracks the electrogram data points to produce a map relative to the electrocardiogram data.

Apparatus for magnetically deployable catheter with MOSFET sensor and method for mapping and ablation

A deflectable stylet is comprised of a hollow tube with a reduced diameter distal portion including a semi-cylindrical ground portion to provide localized flexure wherein tension is applied to an axial tension wire fixed to the distal end of the hollow tube. The hollow tube is coupled to a rotationally fixed tip coupled to a rotationally fixed handle body. The handle body and the tip are telescoped longitudinally with respect to each other along the longitudinal axis of the hollow tube by means of a rotatable nut that advances out of or backs the handle into the tip. The tension wire is coupled to the handle body so that when the nut is rotated in a first direction and the handle body backed out, tension is applied to the wire which is then withdrawn from the hollow tube fixed to the tip causing the stylet to curve at its distal end. Rotation of the nut in the opposite direction reduces the tension on the wire causing the stylet to straighten at its distal end. By this means fine, micrometer adjustments of the curvature of the stylet are reliably and repeatedly made. A conical tip of the handle is coupled to the catheter and provides stress relief to the stylet. The tip is freely rotatable with respect to the handle, but can be locked to the terminal pin of the catheter so that an active fixation pacemaker lead is activatable by rotation of the tip.

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Los Angeles, CA, United States of America

Eli Gang