Florence Medical Ltd.

Elhanan Dgany

Evgeny Shalman

Chen Barak

Simon Henri Noskowicz

Alexander Tyomkin

Alexander Tymonkin

Apparatus for diagnosing lesion severity of a lesion in an arterial lumen supplying blood to a muscle in its non-hyperemic state of a human subject based on processing information relating to the shape of the dicrotic notch of at least one pressure pulse of his proximal non-hyperemic pressure waveform and either the absence of dicrotic notches along his distal non-hyperemic pressure waveform or the shape of the dicrotic notch of at least one pressure pulse of his distal non-hyperemic pressure waveform if present to calculate the value of a PTC parameter indicative of the severity of the lesion.

Apparatus for diagnosing lesion severity, and method therefor

The present invention relates to intravascular pressure measurement based devices and methods determining clinical parameters related to stenosis severity for improved clinical diagnosis and treatment of cardiovascular disease in blood vessels or tubular conduits. More specifically, the invention provides methods for the determination of the clinically significant well known Coronary Flow Reserve (CFR) parameter-previously acquired by velocity measurement devices. In addition Coronary Flow Reserve in the same vessel without stenosis may be estimated and uses to select the necessary medical treatment. Additional pressure based clinical parameters, Diastole to Systole Velocity Ratio (DSVR) and Fractional Flow Reserve (FFR) in stenotic blood vessel during intervention (using only pressure measurements across stenosis) may also be calculated simultaneously, with the same set of interventional devices. Correlation of CFR with these parameters (e.g. FFR) may be further used to estimate the stenosis severity, downstream stenosis and the condition of the vascular bed or conditions related to aneurysms. It is known that there is a correlation between CFR and FFR for healthy vascular bed. Too low value of CRF for given FFR indicates either downstream flow restriction or insufficient infusion of vasodilator. Too high value of CFR for given FFR indicates vascular bed disease.

Method and system for pressure based measurements of CFR and additional clinical hemodynamic parameters

This invention relates to a method and devices for detection, localization and characterization of occlusions, aneurysms, wall characteristics and vascular bed. The invention is based on introducing an artificial pressure or flow excitation signal (a single signal or more) into the blood vessel (or in other tubular flowing fluid conduits), measurement and analysis of the pressure and or flow. The invention discloses a method and devices for detection and characterization of partial or total occlusion or aneurysm in blood vessels or in other tubular flowing fluid conduits within a body, such as urine flow in the urethra.

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Kfar Saba, Israel

Elhanan Dgany