Indena S.p.a.

Eleonora Baldelli

Ezio Bombardelli

Gabriele Fontana

Arturo Battaglia

Andrea Guerrini

Giacomo Carenzi

Donato Pocar

Maria Luisa Gelmi

Cristian Samori

Bruno Danieli

Pocar Donato

A general process for the functionalization at the 14-position of 13-ketobaccatin derivatives of formula I to give derivatives of formula II wherein the substituents are as defined in the disclosure. The conversion of compounds of formula II in compounds of formula III, wherein the substituents are as defined in the disclosure, is also described. 

Taxane derivatives functionalized at the 14-position and a process for the preparation thereof

The present invention relates to an efficient procedure for the synthesis of deserpidine (Ia), starting from reserpic acid lactone (II) via the intermediate 11-O-demethyl reserpic acid lactone (III). 

Process for the semisynthesis of deserpidine

A process for the preparation of 14&#x3b2;-hydroxy-baccatin III-1,14-carbonate useful for the preparation of novel taxane derivatives with antitumor activity.

Process for the preparation of the 14&#x3b2;-hydroxy-baccatin III-1,14-carbonate

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Bologna, Italy

Eleonora Baldelli