University of South Florida

The United States Government As Represented by the Department of Veterans Affairs

Eleni Markoutsa

Shyam S Mohapatra

Subhra Mohapatra

Alejandro J Gonzalez

Heta N Jadhav

The present disclosure relates to exosomes isolated from mesenchymal stem cells exposed to a conditioned media in which microglial cells are cultured in the presence of lipopolysaccharide (LPS) or a beta-amyloid oligomer and uses thereof for reducing inflammation and for treating Alzheimer's disease.

Exosomes isolated from mesenchymal stem cells and uses thereof

This disclosure is directed to therapeutic compositions, and more particularly to microparticle compositions for the controlled delivery of telmisartan and actinomycin D.

Microparticle compositions for controlled delivery of telmisartan and actinomycin D

This invention provides for a RSV-targeted nanoparticle PMN (RTPMN), combining HR2D anti-fusion peptide, and plasmid encoded siRNA against RSV-NS1 and/or RSV-P gene as a safe, effective and inexpensive anti-RSV prophylaxis and/or therapy.

Compositions and methods for treating RSV-infections

A multifunctional dendrimer nanoparticle and method of treating diseases of the posterior segment of the eye is presented. The functionalized polyamidoamine (PAMAM) dendrimer effectively delivers drugs and/or genes to the posterior eye, thereby providing for the effective, non-invasive, and topical treatment of diseased in the posterior eye. The multifunctional dendrimer nanoparticle has shRNA-encoding DNA and small molecule drug encapsulated cyclodextrin complexed to the outer surface of the dendrimer for delivery to the posterior segment of the eye.

Growing community of inventors

Tampa, FL, United States of America

Eleni Markoutsa