Ajinomoto Co., Ltd.

Elena Vitalievna Klyachko

Yuri Ivanovich Kozlov

Mikhail Markovich Gusyatiner

Elvira Borisovna Voroshilova

Vera Georgievna Doroshenko

Larisa Gotlibovna Airikh

Tatyana Viktorovna Leonova

Rustem Saidovich Shakulov

Yoshihiko Hara

Yury Ivanovich Kozlov

Konstantin Vyacheslavovich Rybak

Takuji Ueda

Sergei Vladimirovich Mashko

Ekaterina Aleksandrovna Slivinskaya

Ekaterina Alekseevna Savrasova

Valeriy Zavenovich Akhverdian

Aleksey Nikolaevich Marchenko

Sergey Vladimirovich Benevolensky

Rustam Saidovich Shakulov

Vitaly Grigorievich Paraskevov, Legal Representative

Andrey Yurievich Gulevich

Danila Vadimovich Zimenkov

Yury Ivanovich Koslov

A method for producing an L-amino acid is described, for example, L-phenylalanine and L-histidine, by fermentation using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified by attaching a DNA fragment able to be transcribed encoding the peptide represented in SEQ ID NO: 2, or a variant thereof, particularly a portion of the ssrA gene, to the 3'-end of gene encoding for the bacterial enzyme, which influences on the L-amino acid biosynthesis, such as chorismate mutase/prephenate dehydrogenase or phosphoglucose isomerase.

Method for producing lower alkyl ester

A method for producing an L-amino acid is described, for example, L-phenylalanine and L-histidine, by fermentation using a bacterium of thefamily, wherein the bacterium has been modified by attaching a DNA fragment able to be transcribed encoding the peptide represented in SEQ ID NO: 2, or a variant thereof, particularly a portion of the ssrA gene, to the 3'-end of gene encoding for the bacterial enzyme, which influences on the L-amino acid biosynthesis, such as chorismate mutase/prephenate dehydrogenase or phosphoglucose isomerase.

L-amino acid producing bacterium

There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease.

Method for producing L-amino acids using bacteria of the enterobacteriaceae family

The present invention relates to a mutant bacterial PRPP synthetase which is resistant to feedback by purine nucleotides, and a method for producing L-histidine using the bacterium of the Enterobacteriaceae family wherein the L-amino acid productivity of said bacterium is enhanced by use of the PRPP synthetase which is resistant to feedback by purine nucleotides, coded by the mutant prsA gene.

Mutant phosphoribosylpyrophosphate synthetase and method for producing L-histidine

A method for producing an L-amino acid, such as L-histidine, L-threonine, L-lysine, L-glutamic acid, and L-tryptophan, using bacterium belonging to the genuswhich has increased expression of genes, such as those of the xylABFGHR locus, which encode the xylose utilization enzymes, is disclosed. The method includes cultivating the L-amino acid producing bacterium in a culture medium containing xylose, and collecting the L-amino acid from the culture medium.

Method for producing L-amino acids by fermentation using bacteria having enhanced expression of xylose utilization genes

Method for producing L-amino acids using bacteria of the Enterobacteriaceae family

A method is provided for producing L-histidine using bacterium of the Enterobacteriaceae family wherein the L-amino acid productivity of said bacterium is enhanced by enhancing an activity of the AICAR transformylase-IMP cyclohydrolase encoded by the purH gene.

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The present invention provides a method for producing a non-aromatic L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genusor, which has been modified to attenuate expression of the csrA gene.

A method is provided for producing L-histidine using bacterium of the Enterobacteriaceae family, wherein the L-amino acid productivity of the bacterium is enhanced by enhancing an activity of the transaldolase encoded by the talB gene.

Method for producing L-histidine using bacteria of Enterobacteriaceae family

A method is provided for producing L-histidine using bacterium of the Enterobacteriaceae family, wherein the L-amino acid productivity of said bacterium is enhanced by enhancing an activity of the transaldolase encoded by the talb gene.

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Moscow, Russia

Elena Vitalievna Klyachko