Laboratori Derivati Organici Spa

Consiglio Nazionale Delle Ricerche

Brichima, S.p.a.

Istituto Di Ricerche Chimiche E Biochimiche G Ronzoni

Orange Fiber S.r.l.

Next Technology Tecnotessile Societa Nazionale Di Ricerca R.l.

Instuto Scientifico Di Chimica E Biochimica “G. Rozoni”

Enicham Synthesis

Politecnico Di Milano

Humanitas Mirasole S.p.a.

Emodial S.r.l.

Sachim Srl

Istituto Di Ricerche Chimiche E Biochimiche Giuliana Ronzoni

Elena Vismara

Luigi De Ambrosi

Giangiacomo Torri

Sergio Gonella

Solitario Nesti

Donata Bensi

Carlo Neri

Attilio Citterio

Annamaria Naggi

Francesco Minisci

Luciano Pallini

Silvia De Bernardinis

Mariano Correale

Israel Vlodavsky

Nicola Iannaccone

Lucio Melone

Giangiaocomo Torri

Antonella Bisio

Angelo Alberti

Adriana Maria Santanocito

Sabrina Bertini

Gianluca Ciardelli

Giuseppe Gastaldi

Federico Pecorari

Giuseppe Starace

Paolo Arrigoni

Nicola Iannacone

Alessandro Montanelli

Giorgio Graziani

The present invention is directed to a process for producing spinnable cellulose at least in part from citrus fruits, such as oranges and lemons. In a preferred embodiment, cellulose is extracted from citrus fruits, discarded by the citrus fruits plantations and/or from parts of citrus fruits, waste of the industrial processing of citrus fruits derivatives. Cellulose is extracted from the entire peel of citrus fruits, which includes both albedo and flavedo, or only from albedo. Preferably, cellulose is obtained by chemical extraction, preferably in the absence of chlorine, comprising the treatment of raw materials derived from citrus fruits with hydrogen peroxide under basic conditions. Cellulose obtained by the process of the present invention is optionally mixed with cellulose obtained by different processes, for example with cellulose extracted from wood.

Production of textile from citrus fruit

The present invention is directed to sulfated oligosaccharides having 4, 5 or 6 saccharidic units and wherein a glycosidic bond between two saccharide units is substituted by a C&#x2014;C bond, and wherein the sulfation degree expressed as percentage of OH groups substituted by a OSOgroup is comprised between 50 and 100%. The sulfated oligosaccharides according to the invention are useful as a drug, in particular in the treatment of angiogenesis, metastasis, and inflammation.

Mimetics of sulfated oligosaccharides

The present invention is directed to a multistep process for the physical depolymerization of heparin wherein heparin is subjected to at least two &#x3b3;-ray irradiations and wherein between two irradiation steps the depolymerised heparin is subjected to a separation step and only a fraction of the depolymerised heparin obtained from the first irradiation is subjected to the second irradiation step. It is also directed to heparin-derived oligosaccharide fractions obtainable by the process of the invention.

Multistep process for the physical depolymerization of heparin and products obtained therefrom

Polysaccharides are functionalized using a source of free radicals which forms stable radicals on the polysaccharides structure and wherein the formed radicals reacts with a functionalized unsaturated compound. The method comprises two steps: a first step, wherein the free radical on the polysaccharides chain is formed, and a second step, wherein said radical reacts with the unsaturated compound in the absence of the radical source.

Free-radical functionalized polysaccharides

The invention relates to a process for the depolymerization of glycosaminoglycanes characterized by the use of UVC radiation. The invention also relates to the intermediate depolymerized heparin obtained by the process. The intermediate depolymerized heparin can be dissolved in a buffer solution and fractionated by gel permeation for obtaining the desired molecular weight.

Process for the physical depolymerization of glycosaminoglycanes and products obtained therefrom

The invention relates to a process for the depolymerization of glycosaminoglycanes characterized by the use of electron beam radiation, optionally in the presence of an organic compound selected from the group consisting of ethers, alcohols, aldehydes, amides and formic acid. The invention also relates to the intermediate depolymerized heparin obtained by the process. The intermediate depolymerized heparin can be dissolved in a buffer solution and fractionated by gel permeation for obtaining the desired molecular weight.

Process for the physical depolymerization of glycosaminogylcanes and products obtained thereform

The invention relates to a process for the depolymerization of glycosaminoglycanes characterized by the use of high-energy radiation in the presence of an organic compound selected from the group consisting of ethers, alcohols, aldehydes, amides and formic acid. The invention also relates to intermediate depolymerized heparin having a molecular weight of between 1,000 and 5,500, absorbance at 400 nm below 0.300 and ratio SO/COOequal to or higher than in the starting heparin. The intermediate depolymerized heparin can be dissolved in a buffer solution and fractionated by gel permeation for obtaining the desired molecular weight.

Phenols are oxidated to quinones with hydrogen peroxide in the presence of catalytic amounts of bromine, iodine, hydrogen bromide and hydrogen iodide.

Process for the preparation of quinones

Growing community of inventors

Milan, Italy

Elena Vismara