Chemagis Ltd.

Elgan Pharma Ltd

Elena Ostrovsky

Joseph Kaspi

Oded Arad

Vladimir Naddaka

Michal Olshansky

Shady Saeed

Guy Davidi

Eyal Klopfer

Ofer Sharon

Stav Zeldis

An insulin formulation and a method of preparing and using same. The insulin preparation includes insulin, oligosaccharide and sodium chloride at a ratio of 1:A:B (w:w:w respectively) with ranges of A and B are 1000-5000 and 10-50, respectively.

Insulin formulations and methods of using same in preterm infants

The present invention provides an improved method of chromatographically separating the isomers of (1R,rR)-atracurium salts by high-performance liquid chromatography (HPLC), in the absence of a strong acid. The separation is preferably performed on a silica gel HPLC column using an eluent containing an organic solvent, a polar aprotic co-solvent and a weak organic acid.

(1R, 1'R)-atracurium salts separation process

The present invention provides an improved method for obtaining cisatracurium besylate, which preferably chromatographically separating cisatracurium besylate from a mixture of (1R,1'R)-atracurium isomers via flash chromatography.

(1R,1'R)-atracurium salts separation process

The present invention provides R,R'-atracurium salts, processes for producing and purifying such salts, and methods of using such salts to produce highly pure cisatracurium besylate.

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Rishon Le-Zion, Israel

Elena Ostrovsky