Synta Pharmaceuticals Corporation

Elena Kostik

Lijun Sun

Teresa Przewloka

Mitsunori Ono

Weiwen Ying

Shijie Zhang

Keizo Koya

Howard P Ng

Dinesh U Chimmanamada

Yumiko Wada

Shoujun Chen

David James

Zhi-Qiang Xia

Kevin Paul Foley

Zhenjian Du

James G Barsoum

Noriaki Tatsuta

Junghyun Chae

Takayo Inoue

Chi-Wan Lee

Guiqing Liang

Farid Vaghefi

Zachary Demko

Joanna Dziewiszek

Jun Y Choi

Yuniko Wada

Kevin M Foley

Hao Li

Yaming Wu

Dan Zhou

K Koya

Shije Zhang

The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

Triazone compounds that modulate HSP90 activity

At least 70% by weight of Compound 1 is the single crystalline form, Form A, Form C, or Form D, of the compound. A pharmaceutical composition comprises a pharmaceutically acceptable carrier or diluent, and compound 1, wherein at least 70% by weight of the compound is the single crystalline form, Form A, Form C, or Form D, of the compound. A method of treating a subject with cancer comprises administering to the subject an effective amount of compound 1 or the pharmaceutical composition. 

Polymorphs of N-malonyl-bis(N'-methyl-N&#x2032;-thiobenzoylhydrazide)

Triazole compounds that modulate Hsp90 activity

Disclosed are bis(thio-hydrazide amide) disalts and pharmaceutical compositions thereof. Also disclosed are methods of using bis(thio-hydrazide amide) disalts to treat cancer.

Bis(thio-hydrazide amide) salts for treatment of cancers

Triazole compounds that modulate HSP90 activity

The invention relates to heterocyclic compounds, compositions including the compounds and methods of using and methods of making thereof. The compounds (and compositions) are useful, inter alia, in modulating IL-12 production and processes mediated by IL-12.

IL-12 modulatory compounds

Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I):  Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group. R-Rare independently &#x2014;H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or Rand Rtaken together with the carbon and nitrogen atoms to which they are bonded, and/or Rand Rtaken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. Z is &#x2014;O or &#x2014;S. Mis a pharmaceutically acceptable monovalent cation and Mis a pharmaceutically acceptable divalent cation. Also, disclosed are pharmaceutical compositions comprising a bis(thio-hydrazide amide) disalt described above. Further disclosed are methods of treating a subject with cancer. The methods comprise the step of administering an effective amount of a bis(thio-hydrazide amide) disalt described above.

This invention relates to compounds having a formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, hydrate, prodrug or polymorph thereof wherein X is &#x2014;C(R)&#x2550;N-A. The invention also relates to methods of treating IL-12 overproduction-related disorders, methods of treating or preventing disorders related with excessive bone loss, methods for inhibiting osteoclast formation, and methods for treating or preventing a disorder associated with excessive bone resorption.

Heteroaryl-hydrazone compounds

Disclosed herein is a regioselective synthesis of compounds represented by formula (I): or a salt, solvate, clathrate, or prodrug thereof, wherein X, Y, R, R, R, R, R, R, R, m and n are defined as within.

Process for preparing trisubstituted pyrimidine compounds

This invention relates to compounds of formula (I): their compositions and methods of use thereof. The compounds (and compositions) are useful in modulating IL-12 production and processes mediated by IL-12.

Heteroaryl compounds

Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I):  Also, disclosed are pharmaceutical compositions comprising a bis(thio-hydrazide amide) disalt described above. Further disclosed are methods of treating a subject with cancer. The methods comprise the step of administering an effective amount of a bis(thio-hydrazide amide) disalt described above.

This invention relates to disalt nitrogen-heteroaryl inhibitors of IL-12 production, and related methods and pharmaceutical compositions.

Disalt inhibitors of IL-12 production

Growing community of inventors

Arlington, MA, United States of America

Elena Kostik