Omrix Biopharmaceuticals Inc.

Elena Grimberg

Roberto Meidler

Yonit Tiberman

Nadav Orr

Nadav Ashkenazy

Israel Nur

Erez Ilan

Ronen Eavri

Tamar Auerbach-Nevo

Oleg Belyaev

Itai Podoler

Inbar Gahali-Sass

Shirly Tzelik

The present invention is directed to devices having a substance receiving portion and a membrane constituting the bottom of the substance receiving portion and having such a structure as to allow fluid disposed in the substance receiving portion to be transferred therefrom through the membrane when a vacuum force is applied to the bottom of the substance receiving portion for the purpose of an in-situ preparation of a sample to detect the presence and/or quantify of clottable fibrinogen. The present invention is also directed to corresponding methods, processes and systems.

Device and process for sample preparation

Provided herein are kits comprised of a first container including a solution of fibrinogen-containing component that includes fibrinogen at a concentration range of about 5 mg/ml to about 30 mg/ml, and having a total protein concentration range of about 15 mg/ml to about 40 mg/ml; and a second container that includes a solution of thrombin-containing component. Further provided are mixtures comprised of fibrinogen and thrombin, calcium ions, and albumin, the mixture being comprised of total protein in a range of about 2.5 mg/ml to about 30 mg/ml, fibrinogen in a range of about 50% to about 80% of total protein, and albumin in a range of more than 0.65 mg/ml to about 3 mg/ml. Further provided herein are methods for preventing or reducing tissue adhesion, and hydrogel materials made of fibrin.

Low concentrated protein compositions for preventing tissue adhesion

The present invention is directed to devices having a substance receiving portion; a membrane; and at least one blocking member configured for taking one position and another position to allow fluid communication when a vacuum force is applied to the bottom of the substance receiving portion for the purpose of an in-situ preparation of a sample to detect the presence of, and/or quantify, clottable fibrinogen. The present invention is also directed to corresponding methods, processes and systems.

Provided herein is a plasma-supplemented fibrinogen and/or fibrin formulation, method for the preparation and use thereof.

Plasma-supplemented formulation

Provided is a method, device and system for an in-situ preparation of a sample, for example, for use in detecting the presence of, and/or quantifying, clottable fibrinogen in such a sample.

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Rehovot, Israel

Elena Grimberg