Chemo Research, S.l.

Quimica Sintetica, S.a.

Chemo Iberica, S.a.

Elena Cini

Marcello Rasparini

Maurizio Taddei

Luca Carcone

Giuseppe Barreca

Antonio Zanotti-Gerosa

Giovanni Marras

Stephen James Roseblade

Roberto Rocco Tufaro

Andrea Poggiali

Adele Russo

Renata Riva

Luca Banfi

Romina Vitale

Two processes are described for preparing, in different diastereomeric purity degrees, the compound (S)-isopropyl-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)-phosphoryl)amino) propanoate, having the formula given below, known as Sofosbuvir and used for the treatment of hepatitis C. 

Nucleoside phosphoramidates useful for the treatment of viral infections and preparation thereof

The invention relates to a process for the synthesis of Cariprazine, an antipsychotic compound useful in the treatment of positive and negative symptoms associated to schizophrenia, with the following structural formula: (A) The invention further relates to the synthesis of intermediates useful in the preparation of Cariprazine. 

1,4-cyclohexylamine derivatives and processes for the preparation thereof

A new route of synthesis of the compound Aliskiren of formula (I), used in the treatment of hypertension, is described. 

Process for producing Aliskiren

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Gambassi Terme, Italy

Elena Cini